TY  - JOUR
AU  - Steinberg, S.
AU  - Mors, O.
AU  - Borglum, A.D.
AU  - Gustafsson, O.
AU  - Werge, T.
AU  - Mortensen, P.B.
AU  - Andreassen, O.A.
AU  - Sigurdsson, E.
AU  - Thorgeirsson, T.E.
AU  - Böttcher, Y.
AU  - Olason, P.
AU  - Ophoff, R.A.
AU  - Cichon, S.
AU  - Gudjorsdottir, I.H.
AU  - Pietiläinen, O.P.
AU  - Nyegaard, M.
AU  - Tuulio-Henriksson, A.
AU  - Ingason, A.
AU  - Hansen, T.
AU  - Athansiu, L.
AU  - Luvisaari, J.
AU  - Lonnqvist, J.
AU  - Paunio, T.
AU  - Hartmann, A.
AU  - Jürgens, G.
AU  - Nordentoft, M.
AU  - Hougaard, D.
AU  - Norgaard-Pdersen, B.
AU  - Breuer, R.
AU  - Möller, J.H.
AU  - Giegling, I.
AU  - Glenthoj, B.
AU  - Rasmussen, H.B.
AU  - Mattheisen, M.
AU  - Bitter, I.
AU  - Rethelyi, J.M.
AU  - Sigundsson, T.
AU  - Fossdal, R.
AU  - Thorsteinsdottir, U.
AU  - Ruggeri, M.
AU  - Tosato, S.
AU  - Strengman, E.
AU  - GOUP Kiemeney, L.A.
AU  - Melle, I.
AU  - Djurovic, S.
AU  - Abramova, L.
AU  - Kaleda, V.
AU  - Walshe, M.
AU  - Bramon, E.
AU  - Vassos, E.
AU  - Li, T.
AU  - Fraser, G.
AU  - Walker, N.
AU  - Toulopoulou, T.
AU  - Yoon, J.
AU  - Freimer, N.B.
AU  - Cantor, R.M.
AU  - Murray, R.
AU  - Kong, A.
AU  - Golimbet, V.
AU  - Jönsson, E.G.
AU  - Terenius, L.
AU  - Agartz, I.
AU  - Petursson, H.
AU  - Nöthen, M.M.
AU  - Rietschel, M.
AU  - Peltonen, L.
AU  - Rujescu, D.
AU  - Collier, D.A.
AU  - Stefansson, H.
AU  - St Clair, D.
AU  - Stefansson, K.
TI  - Expanding the range of ZNF804A variants conferring risk of psychosis
JO  - Molecular psychiatry
VL  - 16
SN  - 1359-4184
CY  - London
PB  - Macmillan
M1  - PreJuSER-14635
SP  - 59 - 66
PY  - 2011
N1  - We thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.
AB  - A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10(-8)) associated with schizophrenia earlier. However, one variant, rs1344706[T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10(-7), and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10(-8). In this study, using 5164 schizophrenia cases and 20,709 controls, we replicated the association with schizophrenia (odds ratio OR = 1.08, P = 0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N = 609, OR = 1.09, P = 0.00065). Furthermore, as it has been proposed that variants such as rs1344706[T]-common and with low relative risk-may also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39,481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P = 0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P = 0.0016 for association with the larger set of psychiatric disorders).
KW  - Anxiety Disorders: genetics
KW  - Bipolar Disorder: genetics
KW  - Case-Control Studies
KW  - DNA Copy Number Variations: genetics
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Kruppel-Like Transcription Factors: genetics
KW  - Reference Values
KW  - Schizophrenia: genetics
KW  - Kruppel-Like Transcription Factors (NLM Chemicals)
KW  - ZNF804A protein, human (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20048749
C2  - pmc:PMC3242031
UR  - <Go to ISI:>//WOS:000285546400007
DO  - DOI:10.1038/mp.2009.149
UR  - https://juser.fz-juelich.de/record/14635
ER  -