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@ARTICLE{Floeth:14678,
      author       = {Floeth, F.W. and Sabel, M. and Ewelt, C. and Stummer, W.
                      and Felsberg, J. and Reifenberger, G. and Steiger, H.J. and
                      Stoffels, G. and Coenen, H.H. and Langen, K.J.},
      title        = {{C}omparison of (18){F}-{FET} {PET} and 5-{ALA}
                      fluorescence in cerebral gliomas},
      journal      = {European Journal of Nuclear Medicine and Molecular Imaging},
      volume       = {38},
      number       = {4},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {PreJuSER-14678},
      pages        = {731 - 741},
      year         = {2011},
      note         = {The authors wish to thank Suzanne Schaden and Elisabeth
                      Theelen for assistance in the PET studies; Silke Grafmuller,
                      Erika Wabbals and Sascha Rehbein for radiosynthesis of
                      <SUP>18</SUP>F-FET. This work was supported by the Brain
                      Imaging Center West (BICW).},
      abstract     = {The aim of the study was to compare presurgical
                      (18)F-fluoroethyl-L: -tyrosine ((18)F-FET) uptake and
                      Gd-diethylenetriaminepentaacetic acid (DTPA) enhancement on
                      MRI (Gd) with intraoperative 5-aminolevulinic acid (5-ALA)
                      fluorescence in cerebral gliomas.(18)F-FET positron emission
                      tomography (PET) was performed in 30 patients with brain
                      lesions suggestive of diffuse WHO grade II or III gliomas on
                      MRI. PET and MRI data were coregistered to guide
                      neuronavigated biopsies before resection. After oral
                      application of 5-ALA, 38 neuronavigated biopsies were taken
                      from predefined tumour areas that were positive or negative
                      for (18)F-FET or Gd and checked for 5-ALA fluorescence.
                      (18)F-FET uptake with a mean tumour to brain ratio ≥1.6
                      was rated as positive.Of 38 biopsies, 21 corresponded to
                      high-grade glioma tissue (HGG) of WHO grade III (n = 19)
                      or IV (n = 2) and 17 biopsies to low-grade glioma tissue
                      (LGG) of WHO grade II. In biopsies corresponding to HGG,
                      (18)F-FET PET was positive in $86\%$ (18/21), but 5-ALA and
                      Gd in only $57\%$ (12/21). A mismatch between Gd and 5-ALA
                      was observed in 6 of 21 cases of HGG biopsy samples (3
                      Gd-positive/5-ALA-negative and 3
                      Gd-negative/5-ALA-positive). In biopsies corresponding to
                      LGG, (18)F-FET was positive in $41\%$ (7/17), while 5-ALA
                      and Gd were negative in all but one instance. All tumour
                      areas with 5-ALA fluorescence were positive on (18)F-FET
                      PET.There are differences between (18)F-FET and 5-ALA uptake
                      in cerebral gliomas owing to a limited sensitivity of 5-ALA
                      to detect tumour tissue especially in LGG. (18)F-FET PET is
                      more sensitive to detect glioma tissue than 5-ALA
                      fluorescence and should be considered as an additional tool
                      in resection planning.},
      keywords     = {Adult / Aged / Aminolevulinic Acid: metabolism /
                      Blood-Brain Barrier: metabolism / Brain Neoplasms:
                      metabolism / Brain Neoplasms: pathology / Brain Neoplasms:
                      radionuclide imaging / Female / Gadolinium DTPA: diagnostic
                      use / Glioma: metabolism / Glioma: pathology / Glioma:
                      radionuclide imaging / Humans / Magnetic Resonance Imaging /
                      Male / Middle Aged / Positron-Emission Tomography /
                      Spectrometry, Fluorescence / Tyrosine: analogs $\&$
                      derivatives / Tyrosine: diagnostic use /
                      (18F)fluoroethyltyrosine (NLM Chemicals) / Aminolevulinic
                      Acid (NLM Chemicals) / Tyrosine (NLM Chemicals) / Gadolinium
                      DTPA (NLM Chemicals) / J (WoSType)},
      cin          = {INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Radiology, Nuclear Medicine $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21153408},
      UT           = {WOS:000288255500016},
      doi          = {10.1007/s00259-010-1690-z},
      url          = {https://juser.fz-juelich.de/record/14678},
}