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000001500 0247_ $$2pmid$$apmid:21576123
000001500 0247_ $$2pmc$$apmc:PMC3140817
000001500 0247_ $$2DOI$$a10.1007/s10933-007-9123-0
000001500 0247_ $$2WOS$$aWOS:000254905100002
000001500 037__ $$aPreJuSER-1500
000001500 041__ $$aeng
000001500 082__ $$a930
000001500 084__ $$2WoS$$aEnvironmental Sciences
000001500 084__ $$2WoS$$aGeosciences, Multidisciplinary
000001500 084__ $$2WoS$$aLimnology
000001500 1001_ $$0P:(DE-HGF)0$$aWu, Y.$$b0
000001500 245__ $$aAssessment of nutrient sources and paleoproductivity during the past century in Longgan Lake, middle reaches of the Yangtze River, China
000001500 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2008
000001500 300__ $$a451 - 462
000001500 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000001500 3367_ $$2DRIVER$$aarticle
000001500 440_0 $$012462$$aJournal of Paleolimnology$$v39$$x0921-2728
000001500 500__ $$aRecord converted from VDB: 12.11.2012
000001500 520__ $$aPrevious genome-wide association studies have identified two independent variants in HNF1B as susceptibility loci for prostate cancer risk. To fine-map common genetic variation in this region, we genotyped 79 single nucleotide polymorphisms (SNPs) in the 17q12 region harboring HNF1B in 10 272 prostate cancer cases and 9123 controls of European ancestry from 10 case-control studies as part of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. Ten SNPs were significantly related to prostate cancer risk at a genome-wide significance level of P < 5 × 10(-8) with the most significant association with rs4430796 (P = 1.62 × 10(-24)). However, risk within this first locus was not entirely explained by rs4430796. Although modestly correlated (r(2)= 0.64), rs7405696 was also associated with risk (P = 9.35 × 10(-23)) even after adjustment for rs4430769 (P = 0.007). As expected, rs11649743 was related to prostate cancer risk (P = 3.54 × 10(-8)); however, the association within this second locus was stronger for rs4794758 (P = 4.95 × 10(-10)), which explained all of the risk observed with rs11649743 when both SNPs were included in the same model (P = 0.32 for rs11649743; P = 0.002 for rs4794758). Sequential conditional analyses indicated that five SNPs (rs4430796, rs7405696, rs4794758, rs1016990 and rs3094509) together comprise the best model for risk in this region. This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. Further studies are needed to investigate the biological basis of the association of variants in 17q12 with prostate cancer.
000001500 536__ $$0G:(DE-Juel1)FUEK405$$2G:(DE-HGF)$$aGeosysteme - Erde im Wandel$$cP21$$x0
000001500 588__ $$aDataset connected to Web of Science, Pubmed
000001500 650_2 $$2MeSH$$aAlleles
000001500 650_2 $$2MeSH$$aGenetic Loci: genetics
000001500 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000001500 650_2 $$2MeSH$$aGenome, Human: genetics
000001500 650_2 $$2MeSH$$aHepatocyte Nuclear Factor 1-beta: genetics
000001500 650_2 $$2MeSH$$aHumans
000001500 650_2 $$2MeSH$$aMale
000001500 650_2 $$2MeSH$$aModels, Genetic
000001500 650_2 $$2MeSH$$aPhysical Chromosome Mapping: methods
000001500 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000001500 650_2 $$2MeSH$$aProstatic Neoplasms: genetics
000001500 650_2 $$2MeSH$$aRegression Analysis
000001500 650_2 $$2MeSH$$aRisk Factors
000001500 650_7 $$00$$2NLM Chemicals$$aHNF1B protein, human
000001500 650_7 $$0138674-15-4$$2NLM Chemicals$$aHepatocyte Nuclear Factor 1-beta
000001500 650_7 $$2WoSType$$aJ
000001500 65320 $$2Author$$aorganic carbon
000001500 65320 $$2Author$$aphosphorus
000001500 65320 $$2Author$$aisotopic ratio
000001500 65320 $$2Author$$aanthropogenic source
000001500 65320 $$2Author$$alake productivity
000001500 65320 $$2Author$$aLonggan Lake
000001500 65320 $$2Author$$aChina
000001500 7001_ $$0P:(DE-Juel1)129567$$aLücke, A.$$b1$$uFZJ
000001500 7001_ $$0P:(DE-HGF)0$$aSumin, W.$$b2
000001500 773__ $$0PERI:(DE-600)1478181-5$$a10.1007/s10933-007-9123-0$$gVol. 39, p. 451 - 462$$p451 - 462$$q39<451 - 462$$tJournal of paleolimnology$$v39$$x0921-2728$$y2008
000001500 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140817
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000001500 9141_ $$y2008
000001500 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000001500 9201_ $$0I:(DE-Juel1)VDB143$$d31.12.2001$$gICG$$kICG-5$$lRadioagronomie$$x1
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