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@ARTICLE{Wu:1500,
      author       = {Wu, Y. and Lücke, A. and Sumin, W.},
      title        = {{A}ssessment of nutrient sources and paleoproductivity
                      during the past century in {L}onggan {L}ake, middle reaches
                      of the {Y}angtze {R}iver, {C}hina},
      journal      = {Journal of paleolimnology},
      volume       = {39},
      issn         = {0921-2728},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {PreJuSER-1500},
      pages        = {451 - 462},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Previous genome-wide association studies have identified
                      two independent variants in HNF1B as susceptibility loci for
                      prostate cancer risk. To fine-map common genetic variation
                      in this region, we genotyped 79 single nucleotide
                      polymorphisms (SNPs) in the 17q12 region harboring HNF1B in
                      10 272 prostate cancer cases and 9123 controls of European
                      ancestry from 10 case-control studies as part of the Cancer
                      Genetic Markers of Susceptibility (CGEMS) initiative. Ten
                      SNPs were significantly related to prostate cancer risk at a
                      genome-wide significance level of P < 5 × 10(-8) with the
                      most significant association with rs4430796 (P = 1.62 ×
                      10(-24)). However, risk within this first locus was not
                      entirely explained by rs4430796. Although modestly
                      correlated (r(2)= 0.64), rs7405696 was also associated with
                      risk (P = 9.35 × 10(-23)) even after adjustment for
                      rs4430769 (P = 0.007). As expected, rs11649743 was related
                      to prostate cancer risk (P = 3.54 × 10(-8)); however, the
                      association within this second locus was stronger for
                      rs4794758 (P = 4.95 × 10(-10)), which explained all of the
                      risk observed with rs11649743 when both SNPs were included
                      in the same model (P = 0.32 for rs11649743; P = 0.002 for
                      rs4794758). Sequential conditional analyses indicated that
                      five SNPs (rs4430796, rs7405696, rs4794758, rs1016990 and
                      rs3094509) together comprise the best model for risk in this
                      region. This study demonstrates a complex relationship
                      between variants in the HNF1B region and prostate cancer
                      risk. Further studies are needed to investigate the
                      biological basis of the association of variants in 17q12
                      with prostate cancer.},
      keywords     = {Alleles / Genetic Loci: genetics / Genetic Predisposition
                      to Disease / Genome, Human: genetics / Hepatocyte Nuclear
                      Factor 1-beta: genetics / Humans / Male / Models, Genetic /
                      Physical Chromosome Mapping: methods / Polymorphism, Single
                      Nucleotide: genetics / Prostatic Neoplasms: genetics /
                      Regression Analysis / Risk Factors / HNF1B protein, human
                      (NLM Chemicals) / Hepatocyte Nuclear Factor 1-beta (NLM
                      Chemicals) / J (WoSType)},
      cin          = {ICG-5},
      ddc          = {930},
      cid          = {I:(DE-Juel1)VDB143},
      pnm          = {Geosysteme - Erde im Wandel},
      pid          = {G:(DE-Juel1)FUEK405},
      shelfmark    = {Environmental Sciences / Geosciences, Multidisciplinary /
                      Limnology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21576123},
      pmc          = {pmc:PMC3140817},
      UT           = {WOS:000254905100002},
      doi          = {10.1007/s10933-007-9123-0},
      url          = {https://juser.fz-juelich.de/record/1500},
}