%0 Journal Article
%A Mücke, D.
%A Becker, J.
%A Barbe, Michael
%A Meister, I.
%A Liebhart, L.
%A Röttger, T. B.
%A Dembek, T.
%A Timmermann, L.
%A Grice, M.
%T The Effect of Deep Brain Stimulation on the Speech Motor System
%J Journal of speech, language, and hearing research
%V 57
%@ 1558-9102
%C Rockville, Md.
%I American Speech-Language-Hearing Association
%M FZJ-2014-00417
%P 1206-1218
%D 2014
%X Purpose: Chronic deep brain stimulation of the nucleus ventralis intermedius is an effective treatment for individuals with medication-resistant essential tremor. However, these individuals report that stimulation has a deleterious effect on their speech. The present study investigates one important factor leading to these effects: the coordination of oral and glottal articulation.Method: Sixteen native-speaking German adults with essential tremor, between 26 and 86 years old, with and without chronic deep brain stimulation of the nucleus ventralis intermedius and 12 healthy, age-matched subjects were recorded performing a fast syllable repetition task (/papapa/, /tatata/, /kakaka/). Syllable duration and voicing-to-syllable ratio as well as parameters related directly to consonant production, voicing during constriction, and frication during constriction were measured.Results: Voicing during constriction was greater in subjects with essential tremor than in controls, indicating a perseveration of voicing into the voiceless consonant. Stimulation led to fewer voiceless intervals (voicing-to-syllable ratio), indicating a reduced degree of glottal abduction during the entire syllable cycle. Stimulation also induced incomplete oral closures (frication during constriction), indicating imprecise oral articulation.Conclusion: The detrimental effect of stimulation on the speech motor system can be quantified using acoustic measures at the subsyllabic level.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000348198000006
%R 10.1044/2014_JSLHR-S-13-0155
%U https://juser.fz-juelich.de/record/150347