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@ARTICLE{Mcke:150347,
      author       = {Mücke, D. and Becker, J. and Barbe, Michael and Meister,
                      I. and Liebhart, L. and Röttger, T. B. and Dembek, T. and
                      Timmermann, L. and Grice, M.},
      title        = {{T}he {E}ffect of {D}eep {B}rain {S}timulation on the
                      {S}peech {M}otor {S}ystem},
      journal      = {Journal of speech, language, and hearing research},
      volume       = {57},
      issn         = {1558-9102},
      address      = {Rockville, Md.},
      publisher    = {American Speech-Language-Hearing Association},
      reportid     = {FZJ-2014-00417},
      pages        = {1206-1218},
      year         = {2014},
      abstract     = {Purpose: Chronic deep brain stimulation of the nucleus
                      ventralis intermedius is an effective treatment for
                      individuals with medication-resistant essential tremor.
                      However, these individuals report that stimulation has a
                      deleterious effect on their speech. The present study
                      investigates one important factor leading to these effects:
                      the coordination of oral and glottal articulation.Method:
                      Sixteen native-speaking German adults with essential tremor,
                      between 26 and 86 years old, with and without chronic deep
                      brain stimulation of the nucleus ventralis intermedius and
                      12 healthy, age-matched subjects were recorded performing a
                      fast syllable repetition task (/papapa/, /tatata/,
                      /kakaka/). Syllable duration and voicing-to-syllable ratio
                      as well as parameters related directly to consonant
                      production, voicing during constriction, and frication
                      during constriction were measured.Results: Voicing during
                      constriction was greater in subjects with essential tremor
                      than in controls, indicating a perseveration of voicing into
                      the voiceless consonant. Stimulation led to fewer voiceless
                      intervals (voicing-to-syllable ratio), indicating a reduced
                      degree of glottal abduction during the entire syllable
                      cycle. Stimulation also induced incomplete oral closures
                      (frication during constriction), indicating imprecise oral
                      articulation.Conclusion: The detrimental effect of
                      stimulation on the speech motor system can be quantified
                      using acoustic measures at the subsyllabic level.},
      cin          = {INM-3},
      ddc          = {400},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000348198000006},
      doi          = {10.1044/2014_JSLHR-S-13-0155},
      url          = {https://juser.fz-juelich.de/record/150347},
}