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@ARTICLE{Boller:150349,
      author       = {Boller, J. K. and Barbe, Michael and Pauls, A. M. and Reck,
                      C. and Brand, M. and Maier, F. and Fink, Gereon Rudolf and
                      Timmermann, L. and Kalbe, E.},
      title        = {{D}ecision-making under risk is improved by both
                      dopaminergic medication and subthalamic stimulation in
                      {P}arkinson's disease.},
      journal      = {Experimental neurology},
      volume       = {254},
      issn         = {1090-2430},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2014-00419},
      pages        = {70–77},
      year         = {2014},
      abstract     = {Inconsistent findings regarding the effects of dopaminergic
                      medication (MED) and deep brain stimulation (DBS) of the
                      subthalamic nucleus (STN) on decision making processes and
                      impulsivity in Parkinson's disease (PD) patients have been
                      reported. This study investigated the influence of MED and
                      STN-DBS on decision-making under risk. Eighteen non-demented
                      PD patients, treated with both MED and STN-DBS (64.3 ± 10.2
                      years, UPDRS III MED off, DBS off 45.5 ± 17.1) were tested
                      with the Game of Dice Task (GDT) which probes
                      decision-making under risk during four conditions: MED
                      on/DBS on, MED on/DBS off, MED off/DBS on, and MED off/DBS
                      off. Task performance across conditions was compared
                      analyzing two GDT-parameters: (i) the “net score”
                      indicating advantageous decisions, and (ii) the patient's
                      ability to use negative feedback. Significantly higher GDT
                      net scores were observed in Med on in contrast to Med off
                      conditions as well as in DBS on versus DBS off conditions.
                      However, no effect of therapy for the patient's ability to
                      make use of negative feedback could be detected. The data
                      suggest a positive influence of both MED and STN-DBS on
                      making decisions under risk in PD patients, an effect which
                      seems to be mediated by mechanisms other than the use of
                      negative feedback},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000333321300008},
      pubmed       = {pmid:24444545},
      doi          = {10.1016/j.expneurol.2014.01.005},
      url          = {https://juser.fz-juelich.de/record/150349},
}