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@ARTICLE{Schmitz:150393,
      author       = {Schmitz, Sabine and Brzozowska, Kinga and Pinkawa, Michael
                      and Eble, Michael and Kriehuber, Ralf},
      title        = {{C}hromosomal {R}adiosensitivity {A}nalyzed by {FISH} in
                      {L}ymphocytes of {P}rostate {C}ancer {P}atients and
                      {H}ealthy {D}onors},
      journal      = {Radiation research},
      volume       = {180},
      number       = {5},
      issn         = {1938-5404},
      address      = {Great Falls, Va.},
      publisher    = {Radiation Research Society},
      reportid     = {FZJ-2014-00452},
      pages        = {465 - 473},
      year         = {2013},
      abstract     = {It is known that about $5–10\%$ of cancer patients show
                      severe clinical side effects during and after radiotherapy
                      due to enhanced sensitivity to ionizing radiation.
                      Identification of those radiosensitive individuals by a
                      reliable in vitro assay before onset of treatment would have
                      a great impact on successful radiotherapy. We compared the
                      radiosensitivity of the chromosomes 2, 11 and 17 in prostate
                      cancer patients with and without severe side effects after
                      radiotherapy and in age-matched healthy donors. Each cohort
                      consisted of at least 10 donors. Peripheral blood
                      lymphocytes were irradiated ex vivo with 0.5, 1 und 2 Gy
                      (137Cs γ rays). We investigated the radiosensitivity of the
                      chromosomes 2, 11 and 17 by scoring of 100 FISH painted
                      metaphases for each dose point and donor group. Statistical
                      analyses were performed by nonparametric tests as
                      Mann-Whitney test and Kruskal-Wallis ANOVA, paired Wilcoxon
                      rank test, χ2 goodness-of-fit test and Spearman rank-order
                      correlation at a significance level of P < 0.05. Analysis of
                      the overall aberration yield revealed no significant
                      differences between any donor groups. The translocation
                      frequencies of the chromosomes 2, 11 and 17 coincided with
                      their relative size. Thus, none of the chromosomes analyzed
                      were more or less radiosensitive with respect to the genomic
                      translocation frequency. Additionally, neither of the
                      chromosomes showed enhanced or diminished radiosensitivity
                      in one of the donor groups. Furthermore, variance analyses
                      revealed that the distribution pattern of the aberrations
                      per donor did not differ in each donor group even after
                      exposure to 2 Gy. Prostate cancer patients with and without
                      side effects cannot be distinguished from healthy donors
                      based on aberration yield after irradiation with γ rays.},
      cin          = {S-US},
      ddc          = {610},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000330992700004},
      doi          = {10.1667/RR3239.1},
      url          = {https://juser.fz-juelich.de/record/150393},
}