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@ARTICLE{Hoffstaedter:150580,
      author       = {Hoffstaedter, F. and Grefkes, Christian and Roski,
                      Christian and Caspers, Svenja and Zilles, Karl and Eickhoff,
                      Simon},
      title        = {{A}ge-related decrease of functional connectivity
                      additional to gray matter atrophy in a network for movement
                      initiation.},
      journal      = {Brain structure $\&$ function},
      volume       = {220},
      number       = {2},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2014-00629},
      pages        = {999–1012},
      year         = {2015},
      abstract     = {Healthy aging is accompanied by a decrease in cognitive and
                      motor capacities. In a network associated with movement
                      initiation, we investigated age-related changes of
                      functional connectivity (FC) as well as regional atrophy in
                      a sample of 232 healthy subjects (age range 18-85 years).
                      To this end, voxel-based morphometry and whole-brain
                      resting-state FC were analyzed for the supplementary motor
                      area (SMA), anterior midcingulate cortex (aMCC) and
                      bilateral striatum (Str). To assess the specificity of
                      age-related effects, bilateral primary sensorimotor cortex
                      (S1/M1) closely associated with motor execution was used as
                      control seeds. All regions showed strong reduction of gray
                      matter volume with age. Corrected for this regional atrophy,
                      the FC analysis revealed an age × seed interaction for
                      each of the bilateral Str nodes against S1/M1 with
                      consistent age-related decrease in FC with bilateral caudate
                      nucleus and anterior putamen. Specific age-dependent FC
                      decline of SMA was found in bilateral central insula and the
                      adjacent frontal operculum. aMCC showed exclusive
                      age-related decoupling from the anterior cingulate motor
                      area. The present study demonstrates network as well as
                      node-specific age-dependent FC decline of the SMA and aMCC
                      to highly integrative cortical areas involved in cognitive
                      motor control. FC decrease in addition to gray matter
                      atrophy within the Str may provide a substrate for the
                      declining motor control in elderly. Finally, age-related FC
                      changes in both the network for movement initiation as well
                      as the network for motor execution are not explained by
                      regional atrophy in the healthy aging brain.},
      cin          = {INM-1 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / 572 -
                      (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-571 / G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24399178},
      UT           = {WOS:000350350300024},
      doi          = {10.1007/s00429-013-0696-2},
      url          = {https://juser.fz-juelich.de/record/150580},
}