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@ARTICLE{Miyamoto:150592,
      author       = {Miyamoto, Ko-ichiro and Hirayama, Yuji and Wagner, Torsten
                      and Schöning, Michael J. and Yoshinobu, Tatsuo},
      title        = {{V}isualisation of enzymatic reaktion in a microfluidic
                      channel using chemical imaging sensor},
      journal      = {Electrochimica acta},
      volume       = {113},
      issn         = {0013-4686},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2014-00641},
      pages        = {768 - 772},
      year         = {2013},
      abstract     = {The chemical imaging sensor is a semiconductor-based
                      chemical sensor which is capable of visualizing the spatial
                      distribution of chemical species. In this study, we applied
                      the chemical imaging sensor to a dye-free method of
                      visualizing an enzymatic reaction in a microfluidic channel.
                      Microgel beads loaded with enzyme molecules were trapped in
                      the microchannel. The substrate of the enzyme was injected
                      from the upstream, and then the product of enzymatic
                      reaction was detected in the downstream as pH change. The
                      spatiotemporal change of pH distribution caused by the
                      enzymatic reaction was successfully visualized. The
                      possibility of chemical imaging inside a microchannel also
                      suggests potential application, for example, to
                      chromatography.},
      cin          = {PGI-8 / JARA-FIT / ICS-8},
      ddc          = {540},
      cid          = {I:(DE-Juel1)PGI-8-20110106 / $I:(DE-82)080009_20140620$ /
                      I:(DE-Juel1)ICS-8-20110106},
      pnm          = {423 - Sensorics and bioinspired systems (POF2-423) / 453 -
                      Physics of the Cell (POF2-453)},
      pid          = {G:(DE-HGF)POF2-423 / G:(DE-HGF)POF2-453},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000330491500097},
      doi          = {10.1016/j.electacta.2013.08.089},
      url          = {https://juser.fz-juelich.de/record/150592},
}