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@ARTICLE{Schusser:150598,
author = {Schusser, S. and Poghossian, A. and Bäcker, M. and
Leinhos, M. and Wagner, P. and Schöning, M. J.},
title = {{C}haracterization of biodegradable polymers with
capacitive field-effect sensors.},
journal = {Sensors and actuators / B},
volume = {187},
issn = {0925-4005},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2014-00647},
pages = {2 - 7},
year = {2013},
abstract = {In vitro studies of the degradation kinetic of biopolymers
are essential for the design and optimization of implantable
biomedical devices. In the presented work, a field-effect
capacitive sensor has been applied for the real-time and in
situ monitoring of degradation processes of biopolymers for
the first time. The polymer-covered field-effect sensor is,
in principle, capable to detect any changes in bulk, surface
and interface properties of the polymer induced by
degradation processes. The feasibility of this approach has
been experimentally proven by using the commercially
available biomedical polymer poly(d,l-lactic acid) (PDLLA)
as a model system. PDLLA films of different thicknesses were
deposited on the Ta2O5-gate surface of the field-effect
structure from a polymer solution by means of spin-coating
method. The polymer-modified field-effect sensors have been
characterized by means of capacitance–voltage and
impedance-spectroscopy method. The degradation of the PDLLA
was accelerated by changing the degradation medium from
neutral (pH 7.2) to alkaline (pH 9) condition, resulting in
drastic changes in the capacitance and impedance spectra of
the polymer-modified field-effect sensor.},
cin = {PGI-8 / JARA-FIT / ICS-8},
ddc = {530},
cid = {I:(DE-Juel1)PGI-8-20110106 / $I:(DE-82)080009_20140620$ /
I:(DE-Juel1)ICS-8-20110106},
pnm = {423 - Sensorics and bioinspired systems (POF2-423) / 453 -
Physics of the Cell (POF2-453)},
pid = {G:(DE-HGF)POF2-423 / G:(DE-HGF)POF2-453},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000324298300002},
doi = {10.1016/j.snb.2012.07.099},
url = {https://juser.fz-juelich.de/record/150598},
}