000150599 001__ 150599
000150599 005__ 20240619091111.0
000150599 0247_ $$2doi$$a10.1039/c3an01062g
000150599 0247_ $$2ISSN$$a0003-2654
000150599 0247_ $$2ISSN$$a1364-5528
000150599 0247_ $$2WOS$$aWOS:000325366700005
000150599 0247_ $$2altmetric$$aaltmetric:1688250
000150599 0247_ $$2pmid$$apmid:24003440
000150599 037__ $$aFZJ-2014-00648
000150599 082__ $$a540
000150599 1001_ $$0P:(DE-HGF)0$$aKramer, Friederike$$b0$$eCorresponding author
000150599 245__ $$aBiocatalytic analysis of biomarkers for forensic identification of ethnicity between Caucasian and African American groups.
000150599 260__ $$aCambridge$$bSoc.$$c2013
000150599 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1390917477_7661
000150599 3367_ $$2DataCite$$aOutput Types/Journal article
000150599 3367_ $$00$$2EndNote$$aJournal Article
000150599 3367_ $$2BibTeX$$aARTICLE
000150599 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000150599 3367_ $$2DRIVER$$aarticle
000150599 500__ $$3POF3_Assignment on 2016-02-29
000150599 520__ $$aA new biocatalytic assay analyzing the simultaneous presence of creatine kinase (CK) and lactate dehydrogenase (LDH) was developed aiming at the recognition of biofluids of different ethnic origins for forensic applications. Knowing the difference in the concentrations of CK and LDH in the blood of healthy adults of two ethnical groups, Caucasian (CA) and African American (AA), and taking into account the distribution pattern, we mimicked the samples of different ethnic origins with various CK–LDH concentrations. The analysis was performed using a multi-enzyme/multi-step biocatalytic cascade where the differences in both included enzymes resulted in an amplified difference in the final analytical response. The statistically established analytical results confirmed excellent probability to distinguish samples of different ethnic origins (CA vs. AA). The standard enzymatic assay routinely used in hospitals for the analysis of CK, performed for comparison, was not able to distinguish the difference in samples mimicking blood of different ethnic origins. The robustness of the proposed assay was successfully tested on dried/aged serum samples (up to 24 h) – in order to mimic real forensic situations. The results obtained on the model solutions were confirmed by the analysis of real serum samples collected from human subjects of different ethnic origins.
000150599 536__ $$0G:(DE-HGF)POF2-423$$a423 - Sensorics and bioinspired systems (POF2-423)$$cPOF2-423$$fPOF II$$x0
000150599 536__ $$0G:(DE-HGF)POF2-453$$a453 - Physics of the Cell (POF2-453)$$cPOF2-453$$fPOF II$$x1
000150599 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de
000150599 7001_ $$0P:(DE-HGF)0$$aHalámková, Lenka$$b1
000150599 7001_ $$0P:(DE-Juel1)128717$$aPoghossian, Arshak$$b2$$ufzj
000150599 7001_ $$0P:(DE-Juel1)128727$$aSchöning, Michael J.$$b3$$ufzj
000150599 7001_ $$0P:(DE-HGF)0$$aKatz, Evgeny$$b4
000150599 7001_ $$0P:(DE-HGF)0$$aHalámek, Jan$$b5
000150599 773__ $$0PERI:(DE-600)1472713-4$$a10.1039/c3an01062g$$gVol. 138, no. 21, p. 6251 -$$n21$$p6251 - 6257$$tThe @analyst$$v138$$x1364-5528$$y2013
000150599 8564_ $$uhttps://juser.fz-juelich.de/record/150599/files/FZJ-2014-00648.pdf$$yRestricted$$zPublished final document.
000150599 909CO $$ooai:juser.fz-juelich.de:150599$$pVDB
000150599 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128717$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000150599 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128727$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000150599 9132_ $$0G:(DE-HGF)POF3-559H$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vAddenda$$x0
000150599 9132_ $$0G:(DE-HGF)POF3-529H$$1G:(DE-HGF)POF3-520$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lFuture Information Technology - Fundamentals, Novel Concepts and Energy Efficiency (FIT)$$vAddenda$$x1
000150599 9131_ $$0G:(DE-HGF)POF2-423$$1G:(DE-HGF)POF2-420$$2G:(DE-HGF)POF2-400$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bSchlüsseltechnologien$$lGrundlagen zukünftiger Informationstechnologien$$vSensorics and bioinspired systems$$x0
000150599 9131_ $$0G:(DE-HGF)POF2-453$$1G:(DE-HGF)POF2-450$$2G:(DE-HGF)POF2-400$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bSchlüsseltechnologien$$lBioSoft$$vPhysics of the Cell$$x1
000150599 9141_ $$y2013
000150599 915__ $$0StatID:(DE-HGF)0010$$2StatID$$aJCR/ISI refereed
000150599 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000150599 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000150599 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000150599 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000150599 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000150599 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000150599 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000150599 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000150599 915__ $$0StatID:(DE-HGF)0400$$2StatID$$aAllianz-Lizenz / DFG
000150599 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000150599 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000150599 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000150599 9201_ $$0I:(DE-Juel1)PGI-8-20110106$$kPGI-8$$lBioelektronik$$x0
000150599 9201_ $$0I:(DE-82)080009_20140620$$kJARA-FIT$$lJARA-FIT$$x1
000150599 9201_ $$0I:(DE-Juel1)ICS-8-20110106$$kICS-8$$lBioelektronik$$x2
000150599 980__ $$ajournal
000150599 980__ $$aVDB
000150599 980__ $$aUNRESTRICTED
000150599 980__ $$aI:(DE-Juel1)PGI-8-20110106
000150599 980__ $$aI:(DE-82)080009_20140620
000150599 980__ $$aI:(DE-Juel1)ICS-8-20110106
000150599 981__ $$aI:(DE-Juel1)IBI-3-20200312
000150599 981__ $$aI:(DE-Juel1)ICS-8-20110106