000150620 001__ 150620
000150620 005__ 20210129213236.0
000150620 037__ $$aFZJ-2014-00668
000150620 1001_ $$0P:(DE-Juel1)131679$$aElmenhorst, David$$b0$$eCorresponding author$$ufzj
000150620 1112_ $$aThe XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET  Xith International Conference on Quantification of Brain Function with PET$$cShanghai$$d2013-05-20 - 2013-05-23$$wChina
000150620 245__ $$aAcute ethanol application increases A1 adenosine receptor availability in the human brain
000150620 260__ $$c2013
000150620 3367_ $$0PUB:(DE-HGF)1$$2PUB:(DE-HGF)$$aAbstract$$babstract$$mabstract$$s1390469269_10461
000150620 3367_ $$033$$2EndNote$$aConference Paper
000150620 3367_ $$2DataCite$$aOutput Types/Conference Abstract
000150620 3367_ $$2ORCID$$aOTHER
000150620 3367_ $$2DRIVER$$aconferenceObject
000150620 3367_ $$2BibTeX$$aINPROCEEDINGS
000150620 520__ $$aThe fatiguing and sedating effects of alcohol in humans are supposed to be mediated partially by the inhibitory actions of cerebral adenosine, the main degradation product of ATP. Ethanol is known to increase extracellular adenosine several fold in the brain of rats by an increase in adenosine formation and a decrease of adenosine uptake. Interestingly, it has recently been reported that cerebral A1 adenosine receptor (A1AR) availability measured with [11C]MPDX was increased after ethanol exposure in rats. In the present pilot study we investigated the impact of acute ethanol exposure on A1AR availability in the human brain by the use of PET and the highly selective radioligand [18F]CPFPX. This method has been proved suitable for quantifying A1AR densities in the human brain. A bolus plus constant infusion for steady state quantification allows investigating acute drug interactions like the occupancy of A1AR by caffeine.
In this ongoing study we administered 40 g of ethanol (corresponding to 1 L of beer, n=3) or placebo (n=1) during the steady state period of the PET experiment in healthy volunteers. Ethanol was diluted in 1 L of isotonic NaCl solution and infused intravenously between 80 and 110 min of the 140 min PET scan. Blood alcohol concentration peaked individually between 0.65 and 0.98 mg/mL 30 min after start of the infusion. Arterialized venous blood samples were collected to determine the distribution volume (VT) of [18F]CPFPX by calculating the ratio of the concentrations between tissue and plasma during steady state. The timespan of this ratio represented either baseline (60 to 80 min) or ethanol condition (120 and 140 min). The distribution volumes of various cortical and subcortical regions remained basically constant before and after placebo exposure (relative difference 3%). In contrast, distribution volumes in the ethanol group increased quickly by on average 29%.
Our preliminary data exhibit for the first time a rapid increase in cerebral A1AR availability following acute intravenous ethanol application in humans.
000150620 536__ $$0G:(DE-HGF)POF2-333$$a333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)$$cPOF2-333$$fPOF II$$x0
000150620 7001_ $$0P:(DE-Juel1)138474$$aMatusch, Andreas$$b1$$ufzj
000150620 7001_ $$0P:(DE-Juel1)131691$$aKroll, Tina$$b2$$ufzj
000150620 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b3$$ufzj
000150620 909CO $$ooai:juser.fz-juelich.de:150620$$pVDB
000150620 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131679$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000150620 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)138474$$aForschungszentrum Jülich GmbH$$b1$$kFZJ
000150620 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131691$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000150620 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131672$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000150620 9131_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000150620 9141_ $$y2013
000150620 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
000150620 980__ $$aabstract
000150620 980__ $$aVDB
000150620 980__ $$aUNRESTRICTED
000150620 980__ $$aI:(DE-Juel1)INM-2-20090406