%0 Journal Article
%A Widera, Marek
%A Klein, Antonia Nicole
%A Cinar, Yeliz
%A Funke, Susanne
%A Willbold, Dieter
%A Schaal, Heiner
%T The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
%J AIDS research and therapy
%V 11
%N 1
%@ 1742-6405
%C London
%I BioMed Central
%M FZJ-2014-01123
%P 1 - 7
%D 2014
%X BackgroundAmyloid fibrils such as Semen-Derived Enhancer of Viral Infection (SEVI) or amyloid-β-peptide (Aβ) enhance HIV-1 attachment and entry. Inhibitors destroying or converting those fibrils into non-amyloidogenic aggregates effectively reduce viral infectivity. Thus, they seem to be suitable as therapeutic drugs expanding the current HIV-intervening repertoire of antiretroviral compounds.FindingsIn this study, we demonstrate that the small D-amino acid peptide D3, which was investigated for therapeutic studies on Alzheimer’s disease (AD), significantly reduces both SEVI and Aβ fibril boosted infectivity of HIV-1.ConclusionsSince amyloids could play an important role in the progression of AIDS dementia complex (ADC), the treatment of HIV-1 infected individuals with D3, that inhibits Aβ fibril formation and converts preformed Aβ fibrils into non-amyloidogenic and non-fibrillar aggregates, may reduce the vulnerability of the central nervous system of HIV patients for HIV associated neurological disorders.Keywords:HIV-1 infection; SEVI; D3; Amyloid-beta; Alzheimer’s disease; D-enantiomeric peptide; Drugs; Monomers; Oligomers
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000332026100001
%$ pmid:24422713
%R 10.1186/1742-6405-11-1
%U https://juser.fz-juelich.de/record/151101