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000151101 037__ $$aFZJ-2014-01123
000151101 041__ $$aEnglish
000151101 082__ $$a610
000151101 1001_ $$0P:(DE-HGF)0$$aWidera, Marek$$b0
000151101 245__ $$aThe D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
000151101 260__ $$aLondon$$bBioMed Central$$c2014
000151101 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1410176927_24690
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000151101 520__ $$aBackgroundAmyloid fibrils such as Semen-Derived Enhancer of Viral Infection (SEVI) or amyloid-β-peptide (Aβ) enhance HIV-1 attachment and entry. Inhibitors destroying or converting those fibrils into non-amyloidogenic aggregates effectively reduce viral infectivity. Thus, they seem to be suitable as therapeutic drugs expanding the current HIV-intervening repertoire of antiretroviral compounds.FindingsIn this study, we demonstrate that the small D-amino acid peptide D3, which was investigated for therapeutic studies on Alzheimer’s disease (AD), significantly reduces both SEVI and Aβ fibril boosted infectivity of HIV-1.ConclusionsSince amyloids could play an important role in the progression of AIDS dementia complex (ADC), the treatment of HIV-1 infected individuals with D3, that inhibits Aβ fibril formation and converts preformed Aβ fibrils into non-amyloidogenic and non-fibrillar aggregates, may reduce the vulnerability of the central nervous system of HIV patients for HIV associated neurological disorders.Keywords:HIV-1 infection; SEVI; D3; Amyloid-beta; Alzheimer’s disease; D-enantiomeric peptide; Drugs; Monomers; Oligomers
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000151101 7001_ $$0P:(DE-Juel1)145785$$aKlein, Antonia Nicole$$b1
000151101 7001_ $$0P:(DE-HGF)0$$aCinar, Yeliz$$b2
000151101 7001_ $$0P:(DE-HGF)0$$aFunke, Susanne$$b3$$eCorresponding author
000151101 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b4
000151101 7001_ $$0P:(DE-HGF)0$$aSchaal, Heiner$$b5$$eCorresponding Author
000151101 773__ $$0PERI:(DE-600)2173450-1$$a10.1186/1742-6405-11-1$$gVol. 11, no. 1, p. 1 -$$n1$$p1 - 7$$tAIDS research and therapy$$v11$$x1742-6405$$y2014
000151101 8564_ $$uhttp://www.aidsrestherapy.com/content/11/1/1
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