TY  - JOUR
AU  - Widera, Marek
AU  - Klein, Antonia Nicole
AU  - Cinar, Yeliz
AU  - Funke, Susanne
AU  - Willbold, Dieter
AU  - Schaal, Heiner
TI  - The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
JO  - AIDS research and therapy
VL  - 11
IS  - 1
SN  - 1742-6405
CY  - London
PB  - BioMed Central
M1  - FZJ-2014-01123
SP  - 1 - 7
PY  - 2014
AB  - BackgroundAmyloid fibrils such as Semen-Derived Enhancer of Viral Infection (SEVI) or amyloid-β-peptide (Aβ) enhance HIV-1 attachment and entry. Inhibitors destroying or converting those fibrils into non-amyloidogenic aggregates effectively reduce viral infectivity. Thus, they seem to be suitable as therapeutic drugs expanding the current HIV-intervening repertoire of antiretroviral compounds.FindingsIn this study, we demonstrate that the small D-amino acid peptide D3, which was investigated for therapeutic studies on Alzheimer’s disease (AD), significantly reduces both SEVI and Aβ fibril boosted infectivity of HIV-1.ConclusionsSince amyloids could play an important role in the progression of AIDS dementia complex (ADC), the treatment of HIV-1 infected individuals with D3, that inhibits Aβ fibril formation and converts preformed Aβ fibrils into non-amyloidogenic and non-fibrillar aggregates, may reduce the vulnerability of the central nervous system of HIV patients for HIV associated neurological disorders.Keywords:HIV-1 infection; SEVI; D3; Amyloid-beta; Alzheimer’s disease; D-enantiomeric peptide; Drugs; Monomers; Oligomers
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000332026100001
C6  - pmid:24422713
DO  - DOI:10.1186/1742-6405-11-1
UR  - https://juser.fz-juelich.de/record/151101
ER  -