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@ARTICLE{Widera:151101,
      author       = {Widera, Marek and Klein, Antonia Nicole and Cinar, Yeliz
                      and Funke, Susanne and Willbold, Dieter and Schaal, Heiner},
      title        = {{T}he {D}-amino acid peptide {D}3 reduces amyloid fibril
                      boosted {HIV}-1 infectivity},
      journal      = {AIDS research and therapy},
      volume       = {11},
      number       = {1},
      issn         = {1742-6405},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2014-01123},
      pages        = {1 - 7},
      year         = {2014},
      abstract     = {BackgroundAmyloid fibrils such as Semen-Derived Enhancer of
                      Viral Infection (SEVI) or amyloid-β-peptide (Aβ) enhance
                      HIV-1 attachment and entry. Inhibitors destroying or
                      converting those fibrils into non-amyloidogenic aggregates
                      effectively reduce viral infectivity. Thus, they seem to be
                      suitable as therapeutic drugs expanding the current
                      HIV-intervening repertoire of antiretroviral
                      compounds.FindingsIn this study, we demonstrate that the
                      small D-amino acid peptide D3, which was investigated for
                      therapeutic studies on Alzheimer’s disease (AD),
                      significantly reduces both SEVI and Aβ fibril boosted
                      infectivity of HIV-1.ConclusionsSince amyloids could play an
                      important role in the progression of AIDS dementia complex
                      (ADC), the treatment of HIV-1 infected individuals with D3,
                      that inhibits Aβ fibril formation and converts preformed
                      Aβ fibrils into non-amyloidogenic and non-fibrillar
                      aggregates, may reduce the vulnerability of the central
                      nervous system of HIV patients for HIV associated
                      neurological disorders.Keywords:HIV-1 infection; SEVI; D3;
                      Amyloid-beta; Alzheimer’s disease; D-enantiomeric peptide;
                      Drugs; Monomers; Oligomers},
      cin          = {ICS-6},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000332026100001},
      pubmed       = {pmid:24422713},
      doi          = {10.1186/1742-6405-11-1},
      url          = {https://juser.fz-juelich.de/record/151101},
}