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@ARTICLE{Pannasch:151550,
      author       = {Pannasch, Ulrike and Freche, Dominik and Dallérac, Glenn
                      and Ghézali, Grégory and Escartin, Carole and Ezan, Pascal
                      and Cohen-Salmon, Martine and Benchenane, Karim and Abudara,
                      Veronica and Dufour, Amandine and Lübke, Joachim and
                      Déglon, Nicole and Knott, Graham and Holcman, David and
                      Rouach, Nathalie},
      title        = {{C}onnexin 30 sets synaptic strength by controlling
                      astroglial synapse invasion},
      journal      = {Nature neuroscience},
      volume       = {17},
      number       = {4},
      issn         = {1546-1726},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {FZJ-2014-01451},
      pages        = {549-558},
      year         = {2014},
      abstract     = {Astrocytes play active roles in brain physiology by dynamic
                      interactions with neurons. Connexin 30, one of the two main
                      astroglial gap-junction subunits, is thought to be involved
                      in behavioral and basic cognitive processes. However, the
                      underlying cellular and molecular mechanisms are unknown. We
                      show here in mice that connexin 30 controls hippocampal
                      excitatory synaptic transmission through modulation of
                      astroglial glutamate transport, which directly alters
                      synaptic glutamate levels. Unexpectedly, we found that
                      connexin 30 regulated cell adhesion and migration and that
                      connexin 30 modulation of glutamate transport, occurring
                      independently of its channel function, was mediated by
                      morphological changes controlling insertion of astroglial
                      processes into synaptic clefts. By setting excitatory
                      synaptic strength, connexin 30 plays an important role in
                      long-term synaptic plasticity and in hippocampus-based
                      contextual memory. Taken together, these results establish
                      connexin 30 as a critical regulator of synaptic strength by
                      controlling the synaptic location of astroglial processes.},
      cin          = {INM-2},
      ddc          = {590},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {331 - Signalling Pathways and Mechanisms in the Nervous
                      System (POF2-331) / 89571 - Connectivity and Activity
                      (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-331 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000333405300015},
      pubmed       = {pmid:24584052},
      doi          = {10.1038/nn.3662},
      url          = {https://juser.fz-juelich.de/record/151550},
}