Contribution to a book

FZJ-2014-01650

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Imaging of Adenosine Receptors

Elmenhorst, D. (Corresponding author)FZJ* ; Bier, D.FZJ* ; Holschbach, M.FZJ* ; Bauer, A.FZJ*

2014
Springer Berlin Heidelberg Berlin, Heidelberg
ISBN: 978-3-642-42013-9

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Please use a persistent id in citations: doi:10.1007/978-3-642-42014-6_7

Abstract: Adenosine is a fundamental molecule of life. It is a part of the DNA and the main degradation product of the central currency of energy metabolism in humans and animals – adenosine triphosphate (ATP). Under pathological conditions like hypoxia, the adenosine concentration can rise severalfold – up to micromolar concentrations. The net effect of adenosine on excitable tissue is inhibitory affecting the release of classical neurotransmitters like glutamate, GABA (gamma-aminobutyric acid), and dopamine. The widely used neurostimulant caffeine exerts its effects as an antagonist at adenosine receptors. Four different types of adenosine receptors have been described in mammals: A1, A2A, A2B, and A3 which are all G-protein-coupled receptors. Over the last 25 years, adenosine receptor ligands, agonists as well as antagonists, have emerged as a class of useful therapeutics. For the A1 and A2A subtypes several antagonist radioligands have been used successfully for PET imaging in humans and animals especially for the brain.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Nuklearchemie (INM-5)

Research Program(s):

1. 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333) (POF2-333)

Appears in the scientific report 2014

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