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@ARTICLE{Nellessen:152138,
      author       = {Nellessen, Nils and Rottschy, Claudia and Eickhoff, Simon
                      and Ketteler, Simon T and Kuhn, Hanna and Shah, N. J. and
                      Schulz, Jörg B and Reske, Martina and Reetz, Kathrin},
      title        = {{S}pecific and disease stage-dependent episodic
                      memory-related brain activation patterns in {A}lzheimer's
                      disease: a coordinate-based meta-analysis.},
      journal      = {Brain structure $\&$ function},
      volume       = {220},
      number       = {3},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2014-01928},
      pages        = {1555-1571},
      year         = {2015},
      abstract     = {Episodic memory is typically affected during the course of
                      Alzheimer's disease (AD). Due to the pronounced
                      heterogeneity of functional neuroimaging studies on episodic
                      memory impairments in mild cognitive impairment (MCI) and AD
                      regarding their methodology and findings, we aimed to
                      delineate consistent episodic memory-related brain
                      activation patterns. We performed a systematic,
                      quantitative, coordinate-based whole-brain activation
                      likelihood estimation meta-analysis of 28 functional
                      magnetic resonance imaging (fMRI) studies comprising 292 MCI
                      and 102 AD patients contrasted to 409 age-matched control
                      subjects. We included episodic encoding and/or retrieval
                      phases, investigated the effects of group, verbal or image
                      stimuli and correlated mean Mini-Mental-Status-Examination
                      (MMSE) scores with the modelled activation estimates. MCI
                      patients presented increased right hippocampal activation
                      during memory encoding, decreased activation in the left
                      hippocampus and fusiform gyrus during retrieval tasks, as
                      well as attenuated activation in the right anterior
                      insula/inferior frontal gyrus during verbal retrieval. In AD
                      patients, however, stronger activation within the precuneus
                      during encoding tasks was accompanied by attenuated right
                      hippocampal activation during retrieval tasks. Low cognitive
                      performance (MMSE scores) was associated with stronger
                      activation of the precuneus and reduced activation of the
                      right (para)hippocampus and anterior insula/inferior frontal
                      gyrus. This meta-analysis provides evidence for a specific
                      and probably disease stage-dependent brain activation
                      pattern related to the pathognomonic AD characteristic of
                      episodic memory loss.},
      cin          = {INM-1 / INM-4 / INM-6 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-6-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24633738},
      UT           = {WOS:000353515200022},
      doi          = {10.1007/s00429-014-0744-6},
      url          = {https://juser.fz-juelich.de/record/152138},
}