TY  - JOUR
AU  - Fedosov, Dmitry
AU  - Noguchi, Hiroshi
AU  - Gompper, Gerhard
TI  - Multiscale modeling of blood flow: from single cells to blood rheology
JO  - Biomechanics and modeling in mechanobiology
VL  - 13
IS  - 2
SN  - 1617-7940
CY  - Berlin
PB  - Springer
M1  - FZJ-2014-01949
SP  - 239-258
PY  - 2014
AB  - Mesoscale simulations of blood flow, where the red blood cells are described as deformable closed shells with a membrane characterized by bending rigidity and stretching elasticity, have made much progress in recent years to predict the flow behavior of blood cells and other components in various flows. To numerically investigate blood flow and blood-related processes in complex geometries, a highly efficient simulation technique for the plasma and solutes is essential. In this review, we focus on the behavior of single and several cells in shear and microcapillary flows, the shear-thinning behavior of blood and its relation to the blood cell structure and interactions, margination of white blood cells and platelets, and modeling hematologic diseases and disorders. Comparisons of the simulation predictions with existing experimental results are made whenever possible, and generally very satisfactory agreement is obtained
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000335722700002
DO  - DOI:10.1007/s10237-013-0497-9
UR  - https://juser.fz-juelich.de/record/152169
ER  -