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000015248 0247_ $$2DOI$$a10.1016/j.bbr.2011.04.009
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000015248 084__ $$2WoS$$aBehavioral Sciences
000015248 084__ $$2WoS$$aNeurosciences
000015248 1001_ $$0P:(DE-HGF)0$$aBehrwind, S.D.$$b0
000015248 245__ $$aExecutive control in chronic schizophrenia: A perspective from manual stimulus-response compatibility task performance.
000015248 260__ $$aAmsterdam$$bElsevier$$c2011
000015248 300__ $$a24 - 29
000015248 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000015248 440_0 $$0768$$aBehavioural Brain Research$$v223$$x0166-4328$$y1
000015248 500__ $$aSBE acknowledges funding by the Human Brain Project (R01-MH074457-01A1), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model) and the DFG (IRTG 1328 and ZUK32/1).
000015248 520__ $$aAntisaccade deficits are a well-documented pathophysiological characteristic in schizophrenia. However, it is yet unclear whether these findings reflect a specific oculomotor deficit, general psychomotor impairment or disturbance in executive control mechanisms.Performance in a manual stimulus-response compatibility (SRC) task and a neuropsychological test-battery covering different cognitive and motor domains were obtained in 28 patients with chronic schizophrenia. It was compared with a normative cohort of healthy subjects and validated by comparison with a sub-sample of that cohort consisting of 28 age, gender and education matched controls.Patients showed significantly worse performance than controls in tests requiring maintenance or manipulating of multiple components but were unimpaired in simple motor, memory or executive tasks. In the SRC task patients had a significantly worse performance in the congruent condition and also a significantly higher increase in error rate from the congruent to the incongruent condition. There were, however, neither a group difference nor a group-by-condition interaction with respect to reaction times.: Our results provide evidence against an isolated oculomotor deficit but also against an undifferentiated psychomotor dysfunction in chronic schizophrenia. Rather, in synopsis with previous reports on antisaccade performance, it becomes evident that the degree of impairment follows closely the amount of executive control required in a task, which in turn may relate to dysfunctional top-down bias of the prefrontal cortex arising from unstable task instructions.
000015248 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000015248 65320 $$2Author$$aAntisaccades
000015248 65320 $$2Author$$aNeuropsychology
000015248 65320 $$2Author$$aIntegration
000015248 65320 $$2Author$$aManual
000015248 65320 $$2Author$$aInhibition
000015248 65320 $$2Author$$aExecutive control
000015248 650_2 $$2MeSH$$aChronic Disease
000015248 650_2 $$2MeSH$$aExecutive Function
000015248 650_2 $$2MeSH$$aFemale
000015248 650_2 $$2MeSH$$aHumans
000015248 650_2 $$2MeSH$$aMale
000015248 650_2 $$2MeSH$$aNeuropsychological Tests: statistics & numerical data
000015248 650_2 $$2MeSH$$aPhotic Stimulation: methods
000015248 650_2 $$2MeSH$$aPsychomotor Performance
000015248 650_2 $$2MeSH$$aReaction Time
000015248 650_2 $$2MeSH$$aSchizophrenic Psychology
000015248 650_2 $$2MeSH$$aTrail Making Test: statistics & numerical data
000015248 650_2 $$2MeSH$$aWechsler Scales: statistics & numerical data
000015248 650_7 $$2WoSType$$aJ
000015248 7001_ $$0P:(DE-HGF)0$$aDafotakis, M.$$b1
000015248 7001_ $$0P:(DE-HGF)0$$aHalfter, S.$$b2
000015248 7001_ $$0P:(DE-HGF)0$$aHobusch, K.$$b3
000015248 7001_ $$0P:(DE-HGF)0$$aBerthold-Losleben, M.$$b4
000015248 7001_ $$0P:(DE-Juel1)131855$$aCieslik, E.C.$$b5$$uFZJ
000015248 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b6$$uFZJ
000015248 773__ $$0PERI:(DE-600)2013604-3$$a10.1016/j.bbr.2011.04.009$$gVol. 223, p. 24 - 29$$p24 - 29$$q223<24 - 29$$tBehavioural brain research$$v223$$x0166-4328$$y2011
000015248 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111937
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