TY  - JOUR
AU  - Behrwind, S.D.
AU  - Dafotakis, M.
AU  - Halfter, S.
AU  - Hobusch, K.
AU  - Berthold-Losleben, M.
AU  - Cieslik, E.C.
AU  - Eickhoff, S.B.
TI  - Executive control in chronic schizophrenia: A perspective from manual stimulus-response compatibility task performance.
JO  - Behavioural brain research
VL  - 223
SN  - 0166-4328
CY  - Amsterdam
PB  - Elsevier
M1  - PreJuSER-15248
SP  - 24 - 29
PY  - 2011
N1  - SBE acknowledges funding by the Human Brain Project (R01-MH074457-01A1), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model) and the DFG (IRTG 1328 and ZUK32/1).
AB  - Antisaccade deficits are a well-documented pathophysiological characteristic in schizophrenia. However, it is yet unclear whether these findings reflect a specific oculomotor deficit, general psychomotor impairment or disturbance in executive control mechanisms.Performance in a manual stimulus-response compatibility (SRC) task and a neuropsychological test-battery covering different cognitive and motor domains were obtained in 28 patients with chronic schizophrenia. It was compared with a normative cohort of healthy subjects and validated by comparison with a sub-sample of that cohort consisting of 28 age, gender and education matched controls.Patients showed significantly worse performance than controls in tests requiring maintenance or manipulating of multiple components but were unimpaired in simple motor, memory or executive tasks. In the SRC task patients had a significantly worse performance in the congruent condition and also a significantly higher increase in error rate from the congruent to the incongruent condition. There were, however, neither a group difference nor a group-by-condition interaction with respect to reaction times.: Our results provide evidence against an isolated oculomotor deficit but also against an undifferentiated psychomotor dysfunction in chronic schizophrenia. Rather, in synopsis with previous reports on antisaccade performance, it becomes evident that the degree of impairment follows closely the amount of executive control required in a task, which in turn may relate to dysfunctional top-down bias of the prefrontal cortex arising from unstable task instructions.
KW  - Chronic Disease
KW  - Executive Function
KW  - Female
KW  - Humans
KW  - Male
KW  - Neuropsychological Tests: statistics & numerical data
KW  - Photic Stimulation: methods
KW  - Psychomotor Performance
KW  - Reaction Time
KW  - Schizophrenic Psychology
KW  - Trail Making Test: statistics & numerical data
KW  - Wechsler Scales: statistics & numerical data
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21515312
C2  - pmc:PMC3111937
UR  - <Go to ISI:>//WOS:000292587700004
DO  - DOI:10.1016/j.bbr.2011.04.009
UR  - https://juser.fz-juelich.de/record/15248
ER  -