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@ARTICLE{Behrwind:15248,
      author       = {Behrwind, S.D. and Dafotakis, M. and Halfter, S. and
                      Hobusch, K. and Berthold-Losleben, M. and Cieslik, E.C. and
                      Eickhoff, S.B.},
      title        = {{E}xecutive control in chronic schizophrenia: {A}
                      perspective from manual stimulus-response compatibility task
                      performance.},
      journal      = {Behavioural brain research},
      volume       = {223},
      issn         = {0166-4328},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {PreJuSER-15248},
      pages        = {24 - 29},
      year         = {2011},
      note         = {SBE acknowledges funding by the Human Brain Project
                      (R01-MH074457-01A1), the Initiative and Networking Fund of
                      the Helmholtz Association within the Helmholtz Alliance on
                      Systems Biology (Human Brain Model) and the DFG (IRTG 1328
                      and ZUK32/1).},
      abstract     = {Antisaccade deficits are a well-documented
                      pathophysiological characteristic in schizophrenia. However,
                      it is yet unclear whether these findings reflect a specific
                      oculomotor deficit, general psychomotor impairment or
                      disturbance in executive control mechanisms.Performance in a
                      manual stimulus-response compatibility (SRC) task and a
                      neuropsychological test-battery covering different cognitive
                      and motor domains were obtained in 28 patients with chronic
                      schizophrenia. It was compared with a normative cohort of
                      healthy subjects and validated by comparison with a
                      sub-sample of that cohort consisting of 28 age, gender and
                      education matched controls.Patients showed significantly
                      worse performance than controls in tests requiring
                      maintenance or manipulating of multiple components but were
                      unimpaired in simple motor, memory or executive tasks. In
                      the SRC task patients had a significantly worse performance
                      in the congruent condition and also a significantly higher
                      increase in error rate from the congruent to the incongruent
                      condition. There were, however, neither a group difference
                      nor a group-by-condition interaction with respect to
                      reaction times.: Our results provide evidence against an
                      isolated oculomotor deficit but also against an
                      undifferentiated psychomotor dysfunction in chronic
                      schizophrenia. Rather, in synopsis with previous reports on
                      antisaccade performance, it becomes evident that the degree
                      of impairment follows closely the amount of executive
                      control required in a task, which in turn may relate to
                      dysfunctional top-down bias of the prefrontal cortex arising
                      from unstable task instructions.},
      keywords     = {Chronic Disease / Executive Function / Female / Humans /
                      Male / Neuropsychological Tests: statistics $\&$ numerical
                      data / Photic Stimulation: methods / Psychomotor Performance
                      / Reaction Time / Schizophrenic Psychology / Trail Making
                      Test: statistics $\&$ numerical data / Wechsler Scales:
                      statistics $\&$ numerical data / J (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Behavioral Sciences / Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21515312},
      pmc          = {pmc:PMC3111937},
      UT           = {WOS:000292587700004},
      doi          = {10.1016/j.bbr.2011.04.009},
      url          = {https://juser.fz-juelich.de/record/15248},
}