Hauptseite > Publikationsdatenbank > Executive control in chronic schizophrenia: A perspective from manual stimulus-response compatibility task performance. > print

001     15248
005     20210129210623.0
024 7 _ |2 pmid
|a pmid:21515312
024 7 _ |2 pmc
|a pmc:PMC3111937
024 7 _ |2 DOI
|a 10.1016/j.bbr.2011.04.009
024 7 _ |2 WOS
|a WOS:000292587700004
037 _ _ |a PreJuSER-15248
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Behavioral Sciences
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-HGF)0
|a Behrwind, S.D.
|b 0
245 _ _ |a Executive control in chronic schizophrenia: A perspective from manual stimulus-response compatibility task performance.
260 _ _ |a Amsterdam
|b Elsevier
|c 2011
300 _ _ |a 24 - 29
336 7 _ |0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
|a Journal Article
336 7 _ |2 DataCite
|a Output Types/Journal article
336 7 _ |0 0
|2 EndNote
|a Journal Article
336 7 _ |2 BibTeX
|a ARTICLE
336 7 _ |2 ORCID
|a JOURNAL_ARTICLE
336 7 _ |2 DRIVER
|a article
440 _ 0 |0 768
|a Behavioural Brain Research
|v 223
|x 0166-4328
|y 1
500 _ _ |a SBE acknowledges funding by the Human Brain Project (R01-MH074457-01A1), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model) and the DFG (IRTG 1328 and ZUK32/1).
520 _ _ |a Antisaccade deficits are a well-documented pathophysiological characteristic in schizophrenia. However, it is yet unclear whether these findings reflect a specific oculomotor deficit, general psychomotor impairment or disturbance in executive control mechanisms.Performance in a manual stimulus-response compatibility (SRC) task and a neuropsychological test-battery covering different cognitive and motor domains were obtained in 28 patients with chronic schizophrenia. It was compared with a normative cohort of healthy subjects and validated by comparison with a sub-sample of that cohort consisting of 28 age, gender and education matched controls.Patients showed significantly worse performance than controls in tests requiring maintenance or manipulating of multiple components but were unimpaired in simple motor, memory or executive tasks. In the SRC task patients had a significantly worse performance in the congruent condition and also a significantly higher increase in error rate from the congruent to the incongruent condition. There were, however, neither a group difference nor a group-by-condition interaction with respect to reaction times.: Our results provide evidence against an isolated oculomotor deficit but also against an undifferentiated psychomotor dysfunction in chronic schizophrenia. Rather, in synopsis with previous reports on antisaccade performance, it becomes evident that the degree of impairment follows closely the amount of executive control required in a task, which in turn may relate to dysfunctional top-down bias of the prefrontal cortex arising from unstable task instructions.
536 _ _ |0 G:(DE-Juel1)FUEK409
|2 G:(DE-HGF)
|x 0
|c FUEK409
|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |0 G:(DE-HGF)POF2-89571
|a 89571 - Connectivity and Activity (POF2-89571)
|c POF2-89571
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Chronic Disease
650 _ 2 |2 MeSH
|a Executive Function
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Neuropsychological Tests: statistics & numerical data
650 _ 2 |2 MeSH
|a Photic Stimulation: methods
650 _ 2 |2 MeSH
|a Psychomotor Performance
650 _ 2 |2 MeSH
|a Reaction Time
650 _ 2 |2 MeSH
|a Schizophrenic Psychology
650 _ 2 |2 MeSH
|a Trail Making Test: statistics & numerical data
650 _ 2 |2 MeSH
|a Wechsler Scales: statistics & numerical data
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a Antisaccades
653 2 0 |2 Author
|a Neuropsychology
653 2 0 |2 Author
|a Integration
653 2 0 |2 Author
|a Manual
653 2 0 |2 Author
|a Inhibition
653 2 0 |2 Author
|a Executive control
700 1 _ |0 P:(DE-HGF)0
|a Dafotakis, M.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Halfter, S.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Hobusch, K.
|b 3
700 1 _ |0 P:(DE-HGF)0
|a Berthold-Losleben, M.
|b 4
700 1 _ |0 P:(DE-Juel1)131855
|a Cieslik, E.C.
|b 5
|u FZJ
700 1 _ |0 P:(DE-Juel1)131678
|a Eickhoff, S.B.
|b 6
|u FZJ
773 _ _ |0 PERI:(DE-600)2013604-3
|a 10.1016/j.bbr.2011.04.009
|g Vol. 223, p. 24 - 29
|p 24 - 29
|q 223<24 - 29
|t Behavioural brain research
|v 223
|x 0166-4328
|y 2011
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111937
909 C O |o oai:juser.fz-juelich.de:15248
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