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@ARTICLE{Mirecka:153349,
      author       = {Mirecka, E. A and Shaykhalishahi, H. and Gauhar, A. and
                      Akgül, S. and Lecher, Justin and Willbold, Dieter and
                      Stoldt, Matthias and Hoyer, W.},
      title        = {{S}equestration of a β-{H}airpin for {C}ontrol of
                      α-{S}ynuclein {A}ggregation},
      journal      = {Angewandte Chemie / International edition},
      volume       = {53},
      number       = {16},
      issn         = {0570-0833},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2014-02981},
      pages        = {4227-4230},
      year         = {2014},
      abstract     = {The misfolding and aggregation of the protein α-synuclein
                      (α-syn), which results in the formation of amyloid fibrils,
                      is involved in the pathogenesis of Parkinson's disease and
                      other synucleinopathies. The emergence of amyloid toxicity
                      is associated with the formation of partially folded
                      aggregation intermediates. Here, we engineered a class of
                      binding proteins termed β-wrapins (β-wrap proteins) with
                      affinity for α-synuclein (α-syn). The NMR structure of an
                      α-syn:β-wrapin complex reveals a β-hairpin of α-syn
                      comprising the sequence region α-syn(37-54). The β-wrapin
                      inhibits α-syn aggregation and toxicity at
                      substoichiometric concentrations, demonstrating that it
                      interferes with the nucleation of aggregation.© 2014
                      WILEY-VCH Verlag GmbH $\&$ Co. KGaA, Weinheim.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24623599},
      UT           = {WOS:000338968700022},
      doi          = {10.1002/anie.201309001},
      url          = {https://juser.fz-juelich.de/record/153349},
}