000153359 001__ 153359
000153359 005__ 20210129213728.0
000153359 0247_ $$2doi$$a10.1016/j.cell.2014.02.008
000153359 0247_ $$2ISSN$$a1097-4172
000153359 0247_ $$2ISSN$$a0092-8674
000153359 0247_ $$2WOS$$aWOS:000332945100010
000153359 0247_ $$2altmetric$$aaltmetric:2183065
000153359 0247_ $$2pmid$$apmid:24630722
000153359 037__ $$aFZJ-2014-02990
000153359 082__ $$a570
000153359 1001_ $$0P:(DE-HGF)0$$aLu, Alvin$$b0
000153359 245__ $$aUnified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
000153359 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2014
000153359 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1399880880_4089
000153359 3367_ $$2DataCite$$aOutput Types/Journal article
000153359 3367_ $$00$$2EndNote$$aJournal Article
000153359 3367_ $$2BibTeX$$aARTICLE
000153359 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000153359 3367_ $$2DRIVER$$aarticle
000153359 500__ $$aBitte ändern Sie "Schröder, Gunnar" in "Schröder, Gunnar F." um.
000153359 520__ $$aInflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families of inflammasomes. The adaptor protein ASC bridges the sensor proteins and caspase-1 to form ternary inflammasome complexes, achieved through pyrin domain (PYD) interactions between sensors and ASC and through caspase activation and recruitment domain (CARD) interactions between ASC and caspase-1. We found that PYD and CARD both form filaments. Activated AIM2 and NLRP3 nucleate PYD filaments of ASC, which, in turn, cluster the CARD of ASC. ASC thus nucleates CARD filaments of caspase-1, leading to proximity-induced activation. Endogenous NLRP3 inflammasome is also filamentous. The cryoelectron microscopy structure of ASCPYD filament at near-atomic resolution provides a template for homo- and hetero-PYD/PYD associations, as confirmed by structure-guided mutagenesis. We propose that ASC-dependent inflammasomes in both families share a unified assembly mechanism that involves two successive steps of nucleation-induced polymerization.
000153359 536__ $$0G:(DE-HGF)POF2-452$$a452 - Structural Biology (POF2-452)$$cPOF2-452$$fPOF II$$x0
000153359 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de
000153359 7001_ $$0P:(DE-HGF)0$$aMagupalli, Venkat Giri$$b1
000153359 7001_ $$0P:(DE-HGF)0$$aRuan, Jianbin$$b2
000153359 7001_ $$0P:(DE-HGF)0$$aYin, Qian$$b3
000153359 7001_ $$0P:(DE-HGF)0$$aAtianand, Maninjay K.$$b4
000153359 7001_ $$0P:(DE-HGF)0$$aVos, Matthijn R.$$b5
000153359 7001_ $$0P:(DE-Juel1)132018$$aSchröder, Gunnar F.$$b6
000153359 7001_ $$0P:(DE-HGF)0$$aFitzgerald, Katherine A.$$b7
000153359 7001_ $$0P:(DE-HGF)0$$aWu, Hao$$b8$$eCorresponding Author
000153359 7001_ $$0P:(DE-HGF)0$$aEgelman, Edward H.$$b9
000153359 773__ $$0PERI:(DE-600)2001951-8$$a10.1016/j.cell.2014.02.008$$gVol. 156, no. 6, p. 1193 - 1206$$n6$$p1193 - 1206$$tCell$$v156$$x0092-8674$$y2014
000153359 8564_ $$uhttp://www.cell.com/abstract/S0092-8674%2814%2900200-1
000153359 8564_ $$uhttps://juser.fz-juelich.de/record/153359/files/FZJ-2014-02990.pdf$$yRestricted
000153359 909CO $$ooai:juser.fz-juelich.de:153359$$pVDB
000153359 9141_ $$y2014
000153359 915__ $$0StatID:(DE-HGF)0040$$2StatID$$aPeer review unknown
000153359 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000153359 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000153359 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000153359 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000153359 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000153359 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000153359 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000153359 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000153359 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000153359 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000153359 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000153359 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132018$$aForschungszentrum Jülich GmbH$$b6$$kFZJ
000153359 9132_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000153359 9131_ $$0G:(DE-HGF)POF2-452$$1G:(DE-HGF)POF2-450$$2G:(DE-HGF)POF2-400$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bSchlüsseltechnologien$$lBioSoft$$vStructural Biology$$x0
000153359 920__ $$lyes
000153359 9201_ $$0I:(DE-Juel1)ICS-6-20110106$$kICS-6$$lStrukturbiochemie$$x0
000153359 980__ $$ajournal
000153359 980__ $$aVDB
000153359 980__ $$aI:(DE-Juel1)ICS-6-20110106
000153359 980__ $$aUNRESTRICTED
000153359 981__ $$aI:(DE-Juel1)IBI-7-20200312