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@INPROCEEDINGS{Pool:153471,
      author       = {Pool, EM and Eickhoff, Simon and Fink, Gereon Rudolf and
                      Grefkes, C.},
      title        = {{F}unctional resting-state connectivity of the human motor
                      network: {D}ifferences between right- and left-handers},
      journal      = {Klinische Neurophysiologie},
      volume       = {45},
      number       = {01},
      issn         = {1439-4081},
      address      = {Stuttgart [u.a.]},
      publisher    = {Thieme},
      reportid     = {FZJ-2014-03069},
      pages        = {s-0034-1371279},
      year         = {2014},
      abstract     = {Background: Handedness, i.e., the preference to use one
                      hand over the other, has been shown to be associated with
                      differences in activation levels in various motor tasks
                      performed with the dominant or non-dominant hand (Gilbert
                      $\&$ Wysocki, 1992; White et al., 1994). We were interested
                      whether also in the absence of an overt motor task, i.e.,
                      during “resting-state”, spontaneous fluctuations of
                      primary motor cortex activity shows differential functional
                      connectivity in the left or right hemisphere depending on
                      whether subjects report left- or right-handedness.Methods:
                      We, therefore, scanned 24 volunteers (12 right-handers and
                      12 left-handers) with resting-state functional magnetic
                      resonance imaging (rs-fMRI). Handedness was assessed by the
                      Edinburgh-Handedness-Inventory (EHI) that ranges from -100
                      (strongly left-handed) to +100 (strongly right-handed). We
                      computed two explorative whole-brain group analyses where
                      the time course within a sphere of 8 mm-diameters centered
                      on the M1 seed voxel (“hand knob” formation) was
                      correlated with every other voxel in the brain. To test for
                      differences in functional connectivity between right- and
                      left-handers, we used M1 (left/right) as seed region to
                      consider both the “dominant” (left) M1 of right-handers
                      and the “dominant” (right) M1 of the left-handers. We,
                      then, computed regression analyses including resting-state
                      connectivity and EHI as covariates.Results: We found a
                      positive correlation between EHI and resting-state
                      functional connectivity of left M1 with the left
                      supplementary motor area (SMA). That is, the stronger the
                      M1-SMA functional connectivity within the left hemisphere
                      during rest, the stronger the preference to use the right
                      hand for manual skills (P< 0.05 FWE-corrected on the
                      voxel-level). The reverse contrast did not yield significant
                      voxels. Likewise, multiple regression analyses between EHI
                      and resting-state connectivity of right M1 not reveal
                      differences between right- and left-handers.Conclusion: Our
                      results show that functional connectivity of the human motor
                      cortex differs between right- and left-handers, even in the
                      absence of overt motor performance. Right-handedness is
                      predicted by a stronger functional connectivity between left
                      SMA and left M1. An intrinsically higher connectivity of the
                      dominant motor cortex with premotor areas in right-handers
                      might explain the behavioural notion that right-handedness
                      is usually strongly lateralised while left-handers are more
                      flexible in also using their non-dominant hand in activities
                      of daily living.},
      month         = {Mar},
      date          = {2014-03-19},
      organization  = {58. Jahrestagung der Deutschen
                       Gesellschaft für Klinische
                       Neurophysiologie und Funktionelle
                       Bildgebung (DGKN), Berlin (Germany), 19
                       Mar 2014 - 22 Mar 2014},
      cin          = {INM-3 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)8 / PUB:(DE-HGF)16},
      doi          = {10.1055/s-0034-1371279},
      url          = {https://juser.fz-juelich.de/record/153471},
}