TY  - CONF
AU  - Nettekoven, C.
AU  - Volz, LJ
AU  - Kutscha, M.
AU  - Eickhoff, Simon
AU  - Grefkes, C.
TI  - Are individual responses to theta-burst rTMS in cortical excitability related to changes in motor network connectivity?
JO  - Klinische Neurophysiologie
VL  - 45
IS  - 01
SN  - 1439-4081
CY  - Stuttgart [u.a.]
PB  - Thieme
M1  - FZJ-2014-03070
SP  - V22
PY  - 2014
AB  - Intermittent theta-burst stimulation (iTBS) effectively increases cortical excitability within the human brain (Huang et al., 2005). However, individual after-effects of iTBS vary between subjects, with a large proportion not responding at all in terms of changes in excitability (Ridding and Ziemann, 2010; Hamada et al., 2013). We here investigated whether subjects responding to iTBS show differential changes in resting-state functional connectivity (rsFC) within the cortical motor system compared to subjects with no response.14 healthy, right-handed subjects (m = 7, 27 ± 3 years) received iTBS over the left primary motor cortex (M1) on two days, separated by at least one week. Before and after iTBS-application (i) motor-evoked potentials (MEPs) or (ii) resting-state functional magnetic resonance imaging (fMRI) was assessed. Seed-based whole-brain rsFC was computed for the stimulated M1.Subjects were divided into groups of responders and non-responders according to iTBS-induced changes in MEPs (criterion: increase of at least 10% compared to baseline). Following iTBS, rsFC between M1 and premotor areas was significantly higher in responders compared to both baseline (p ≤0.001, FWE-corrected) and non-responders (p ≤0.001, FWE-corrected). Furthermore, non-responders featured higher levels of pre-interventional rsFC compared to responders (p = 0.061, FWE-corrected). Individual changes in MEPs and rsFC did not correlate.Significant iTBS-induced modulations of rsFC were exclusively found for the group of iTBS-responders, suggesting that changes in cortical excitability and motor network rsFC are related. However, no linear correlation between changes in MEP-amplitudes and rsFC was evident. Furthermore, higher levels of pre-interventional rsFC might prevent iTBS-induced strengthening of premotor-M1 connections, possibly underlying the non-responsiveness to iTBS
T2  - 58. Jahrestagung der Deutschen Gesellschaft für Klinische Neurophysiologie und Funktionelle Bildgebung (DGKN)
CY  - 19 Mar 2014 - 22 Mar 2014, Berlin (Germany)
Y2  - 19 Mar 2014 - 22 Mar 2014
M2  - Berlin, Germany
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)16
DO  - DOI:10.1055/s-0034-1371201
UR  - https://juser.fz-juelich.de/record/153472
ER  -