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@INPROCEEDINGS{Nettekoven:153472,
      author       = {Nettekoven, C. and Volz, LJ and Kutscha, M. and Eickhoff,
                      Simon and Grefkes, C.},
      title        = {{A}re individual responses to theta-burst r{TMS} in
                      cortical excitability related to changes in motor network
                      connectivity?},
      journal      = {Klinische Neurophysiologie},
      volume       = {45},
      number       = {01},
      issn         = {1439-4081},
      address      = {Stuttgart [u.a.]},
      publisher    = {Thieme},
      reportid     = {FZJ-2014-03070},
      pages        = {V22},
      year         = {2014},
      abstract     = {Intermittent theta-burst stimulation (iTBS) effectively
                      increases cortical excitability within the human brain
                      (Huang et al., 2005). However, individual after-effects of
                      iTBS vary between subjects, with a large proportion not
                      responding at all in terms of changes in excitability
                      (Ridding and Ziemann, 2010; Hamada et al., 2013). We here
                      investigated whether subjects responding to iTBS show
                      differential changes in resting-state functional
                      connectivity (rsFC) within the cortical motor system
                      compared to subjects with no response.14 healthy,
                      right-handed subjects (m = 7, 27 ± 3 years) received iTBS
                      over the left primary motor cortex (M1) on two days,
                      separated by at least one week. Before and after
                      iTBS-application (i) motor-evoked potentials (MEPs) or (ii)
                      resting-state functional magnetic resonance imaging (fMRI)
                      was assessed. Seed-based whole-brain rsFC was computed for
                      the stimulated M1.Subjects were divided into groups of
                      responders and non-responders according to iTBS-induced
                      changes in MEPs (criterion: increase of at least $10\%$
                      compared to baseline). Following iTBS, rsFC between M1 and
                      premotor areas was significantly higher in responders
                      compared to both baseline (p ≤0.001, FWE-corrected) and
                      non-responders (p ≤0.001, FWE-corrected). Furthermore,
                      non-responders featured higher levels of pre-interventional
                      rsFC compared to responders (p = 0.061, FWE-corrected).
                      Individual changes in MEPs and rsFC did not
                      correlate.Significant iTBS-induced modulations of rsFC were
                      exclusively found for the group of iTBS-responders,
                      suggesting that changes in cortical excitability and motor
                      network rsFC are related. However, no linear correlation
                      between changes in MEP-amplitudes and rsFC was evident.
                      Furthermore, higher levels of pre-interventional rsFC might
                      prevent iTBS-induced strengthening of premotor-M1
                      connections, possibly underlying the non-responsiveness to
                      iTBS},
      month         = {Mar},
      date          = {2014-03-19},
      organization  = {58. Jahrestagung der Deutschen
                       Gesellschaft für Klinische
                       Neurophysiologie und Funktionelle
                       Bildgebung (DGKN), Berlin (Germany), 19
                       Mar 2014 - 22 Mar 2014},
      cin          = {INM-3 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)8 / PUB:(DE-HGF)16},
      doi          = {10.1055/s-0034-1371201},
      url          = {https://juser.fz-juelich.de/record/153472},
}