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@ARTICLE{Fedosov:153934,
      author       = {Fedosov, Dmitry A. and Gompper, Gerhard},
      title        = {{W}hite blood cell margination in microcirculation},
      journal      = {Soft matter},
      volume       = {10},
      number       = {17},
      issn         = {1744-6848},
      address      = {Cambridge},
      publisher    = {Royal Society of Chemistry (RSC)},
      reportid     = {FZJ-2014-03387},
      pages        = {2961 -2970},
      year         = {2014},
      abstract     = {Proper functioning of white blood cells is not possible
                      without their ability to adhere to vascular endothelium,
                      which may occur only if they are close enough to vessel
                      walls. To facilitate the adhesion, white blood cells migrate
                      toward the vessel walls in blood flow through a process
                      called margination. The margination of white cells depends
                      on a number of conditions including local hematocrit, flow
                      rate, red blood cell aggregation, and the deformability of
                      both red and white cells. To better understand the
                      margination process of white blood cells, we employ
                      mesoscopic hydrodynamic simulations of a three-dimensional
                      model of blood flow, which has been previously shown to
                      capture quantitatively realistic blood flow properties and
                      rheology. The margination properties of white blood cells
                      are studied for a wide range of hematocrit values and flow
                      conditions. Efficient white blood cell margination is found
                      in an intermediate range of hematocrit values of Ht ≈
                      0.2–0.4 and at relatively low flow rates, characteristic
                      of the venular part of microcirculation. In addition,
                      aggregation interactions between red blood cells lead to
                      enhanced white-blood-cell margination. This simulation study
                      provides a quantitative description of the margination of
                      white blood cells, and is also highly relevant for the
                      margination of particles or cells of similar size such as
                      circulating tumor cells.},
      cin          = {IAS-2 / ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {451 - Soft Matter Composites (POF2-451)},
      pid          = {G:(DE-HGF)POF2-451},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000334494000006},
      pubmed       = {pmid:24695813},
      doi          = {10.1039/c3sm52860j},
      url          = {https://juser.fz-juelich.de/record/153934},
}