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000153936 041__ $$aEnglish
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000153936 1001_ $$0P:(DE-Juel1)145415$$aMüller, Kathrin$$b0$$eCorresponding Author$$ufzj
000153936 245__ $$aMargination of micro- and nano-particles in blood flow and its effect on drug delivery
000153936 260__ $$aLondon$$bNature Publishing Group$$c2014
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000153936 520__ $$aDrug delivery by micro- and nano-carriers enables controlled transport of pharmaceuticals to targeted sites. Even though carrier fabrication has made much progress recently, the delivery including controlled particle distribution and adhesion within the body remains a great challenge. The adhesion of carriers is strongly affected by their margination properties (migration toward walls) in the microvasculature. To investigate margination characteristics of carriers of different shapes and sizes and to elucidate the relevant physical mechanisms, we employ mesoscopic hydrodynamic simulations of blood flow. Particle margination is studied for a wide range of hematocrit values, vessel sizes, and flow rates, using two- and three-dimensional models. The simulations show that the margination properties of particles improve with increasing carrier size. Spherical particles yield slightly better margination than ellipsoidal carriers; however, ellipsoidal particles exhibit a slower rotational dynamics near a wall favoring their adhesion. In conclusion, micron-sized ellipsoidal particles are favorable for drug delivery in comparison with sub-micron spherical particles
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000153936 7001_ $$0P:(DE-HGF)0$$aFedosov, Dmitry A.$$b1
000153936 7001_ $$0P:(DE-Juel1)130665$$aGompper, Gerhard$$b2$$ufzj
000153936 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/srep04871$$gVol. 4$$p4871$$tScientific reports$$v4$$x2045-2322$$y2014
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000153936 9141_ $$y2014
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000153936 9132_ $$0G:(DE-HGF)POF3-553$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vPhysical Basis of Diseases$$x0
000153936 9131_ $$0G:(DE-HGF)POF2-451$$1G:(DE-HGF)POF2-450$$2G:(DE-HGF)POF2-400$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bSchlüsseltechnologien$$lBioSoft$$vSoft Matter Composites$$x0
000153936 9201_ $$0I:(DE-Juel1)IAS-2-20090406$$kIAS-2$$lTheorie der Weichen Materie und Biophysik$$x0
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