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@ARTICLE{Mller:153936,
      author       = {Müller, Kathrin and Fedosov, Dmitry A. and Gompper,
                      Gerhard},
      title        = {{M}argination of micro- and nano-particles in blood flow
                      and its effect on drug delivery},
      journal      = {Scientific reports},
      volume       = {4},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2014-03389},
      pages        = {4871},
      year         = {2014},
      abstract     = {Drug delivery by micro- and nano-carriers enables
                      controlled transport of pharmaceuticals to targeted sites.
                      Even though carrier fabrication has made much progress
                      recently, the delivery including controlled particle
                      distribution and adhesion within the body remains a great
                      challenge. The adhesion of carriers is strongly affected by
                      their margination properties (migration toward walls) in the
                      microvasculature. To investigate margination characteristics
                      of carriers of different shapes and sizes and to elucidate
                      the relevant physical mechanisms, we employ mesoscopic
                      hydrodynamic simulations of blood flow. Particle margination
                      is studied for a wide range of hematocrit values, vessel
                      sizes, and flow rates, using two- and three-dimensional
                      models. The simulations show that the margination properties
                      of particles improve with increasing carrier size. Spherical
                      particles yield slightly better margination than ellipsoidal
                      carriers; however, ellipsoidal particles exhibit a slower
                      rotational dynamics near a wall favoring their adhesion. In
                      conclusion, micron-sized ellipsoidal particles are favorable
                      for drug delivery in comparison with sub-micron spherical
                      particles},
      cin          = {IAS-2 / ICS-2},
      ddc          = {000},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {451 - Soft Matter Composites (POF2-451)},
      pid          = {G:(DE-HGF)POF2-451},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000335216800007},
      pubmed       = {pmid:24786000},
      doi          = {10.1038/srep04871},
      url          = {https://juser.fz-juelich.de/record/153936},
}