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@ARTICLE{Pool:153969,
      author       = {Pool, Eva-Maria and Rehme, Anne K. and Fink, Gereon R. and
                      Eickhoff, Simon and Grefkes, Christian},
      title        = {{H}andedness and effective connectivity of the motor
                      system},
      journal      = {NeuroImage},
      volume       = {99},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2014-03402},
      pages        = {451–460},
      year         = {2014},
      abstract     = {Handedness denotes the individual predisposition to
                      consistently use the left or right hand for most types of
                      skilled movements. A putative neurobiological mechanism for
                      handedness consists in hemisphere-specific differences in
                      network dynamics that govern unimanual movements.We,
                      therefore, used functional magnetic resonance imaging and
                      dynamic causal modeling to investigate effective
                      connectivity between key motor areas during fist closures of
                      the dominant or non-dominant hand performed by 18 right- and
                      18 left-handers. Handedness was assessed employing the
                      Edinburgh-Handedness-Inventory (EHI). The network of
                      interest consisted of key motor regions in both hemispheres
                      including the primary motor cortex (M1), supplementary motor
                      area (SMA), ventral premotor cortex (PMv), motor putamen
                      (Put) and motor cerebellum (Cb).The connectivity analysis
                      revealed that in right-handed subjects movements of the
                      dominant hand were associated with significantly stronger
                      coupling of contralateral (left, i.e., dominant) SMA with
                      ipsilateral SMA, ipsilateral PMv, contralateral motor
                      putamen and contralateral M1 compared to equivalent
                      connections in left-handers. The degree of handedness as
                      indexed by the individual EHI scores also correlated with
                      coupling parameters of these connections. In contrast, we
                      found no differences between right- and left-handers when
                      testing for the effect of movement speed on effective
                      connectivity.In conclusion, the data show that handedness is
                      associated with differences in effective connectivity within
                      the human motor network with a prominent role of SMA in
                      right-handers. Left-handers featured less asymmetry in
                      effective connectivity implying different hemispheric
                      mechanisms underlying hand motor control compared to
                      right-handers.},
      cin          = {INM-1 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89571 - Connectivity and
                      Activity (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000339860000045},
      pubmed       = {pmid:24862079},
      doi          = {10.1016/j.neuroimage.2014.05.048},
      url          = {https://juser.fz-juelich.de/record/153969},
}