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000154031 0247_ $$2doi$$a10.1007/s10439-013-0922-3
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000154031 037__ $$aFZJ-2014-03445
000154031 041__ $$aEnglish
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000154031 1001_ $$0P:(DE-Juel1)140336$$aFedosov, Dmitry$$b0
000154031 245__ $$aComputational biorheology of human blood flow in health and disease
000154031 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2014
000154031 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1402639068_14237
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000154031 520__ $$aHematologic disorders arising from infectious diseases, hereditary factors and environmental influences can lead to, and can be influenced by, significant changes in the shape, mechanical and physical properties of red blood cells (RBCs), and the biorheology of blood flow. Hence, modeling of hematologic disorders should take into account the multiphase nature of blood flow, especially in arterioles and capillaries. We present here an overview of a general computational framework based on dissipative particle dynamics (DPD) which has broad applicability in cell biophysics with implications for diagnostics, therapeutics and drug efficacy assessments for a wide variety of human diseases. This computational approach, validated by independent experimental results, is capable of modeling the biorheology of whole blood and its individual components during blood flow so as to investigate cell mechanistic processes in health and disease. DPD is a Lagrangian method that can be derived from systematic coarse-graining of molecular dynamics but can scale efficiently up to arterioles and can also be used to model RBCs down to the spectrin level. We start from experimental measurements of a single RBC to extract the relevant biophysical parameters, using single-cell measurements involving such methods as optical tweezers, atomic force microscopy and micropipette aspiration, and cell-population experiments involving microfluidic devices. We then use these validated RBC models to predict the biorheological behavior of whole blood in healthy or pathological states, and compare the simulations with experimental results involving apparent viscosity and other relevant parameters. While the approach discussed here is sufficiently general to address a broad spectrum of hematologic disorders including certain types of cancer, this paper specifically deals with results obtained using this computational framework for blood flow in malaria and sickle cell anemia.
000154031 536__ $$0G:(DE-HGF)POF2-451$$a451 - Soft Matter Composites (POF2-451)$$cPOF2-451$$fPOF II$$x0
000154031 7001_ $$0P:(DE-HGF)0$$aDao, M.$$b1
000154031 7001_ $$0P:(DE-HGF)0$$aKarniadakis, G. E.$$b2$$eCorresponding Author
000154031 7001_ $$0P:(DE-HGF)0$$aSuresh, S.$$b3
000154031 773__ $$0PERI:(DE-600)1477155-x$$a10.1007/s10439-013-0922-3$$n2$$p368-387$$tAnnals of biomedical engineering$$v42$$x0191-5649$$y2014
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000154031 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)140336$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
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000154031 9141_ $$y2014
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000154031 9201_ $$0I:(DE-Juel1)IAS-2-20090406$$kIAS-2$$lTheorie der Weichen Materie und Biophysik $$x0
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