% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Caspers:154147,
      author       = {Caspers, S. and Moebus, S. and Lux, S. and Pundt, N. and
                      Schütz, H. and Mühleisen, Thomas and Gras, V. and
                      Eickhoff, Simon and Romanzetti, S. and Stöcker, T. and
                      Stirnberg, R. and Kirlangic, M. E. and Minnerop, M. and
                      Pieperhoff, P. and Mödder, U. and Das, S. and Evans, A. and
                      Jöckel, K. H. and Erbel, R. and Cichon, S. and Nöthen, M.
                      M. and Sturma, D. and Bauer, Andreas and Shah, N. J. and
                      Zilles, K. and Amunts, K.},
      title        = {{S}tudying variability in human brain aging in a
                      population-based {G}erman cohort – {R}ationale and design
                      of 1000{BRAINS}},
      journal      = {Frontiers in aging neuroscience},
      volume       = {6},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2014-03540},
      pages        = {149},
      year         = {2014},
      abstract     = {The ongoing 1000 brains study (1000BRAINS) is an
                      epidemiological and neuroscientific investigation of
                      structural and functional variability in the human brain
                      during aging. The two recruitment sources are the 10-year
                      follow-up cohort of the German Heinz Nixdorf Recall (HNR)
                      Study, and the HNR MultiGeneration Study cohort, which
                      comprises spouses and offspring of HNR subjects. The HNR is
                      a longitudinal epidemiological investigation of
                      cardiovascular risk factors, with a comprehensive collection
                      of clinical, laboratory, socioeconomic, and environmental
                      data from population-based subjects aged 45–75 years on
                      inclusion. HNR subjects underwent detailed assessments in
                      2000, 2006, and 2011, and completed annual postal
                      questionnaires on health status. 1000BRAINS accesses these
                      HNR data and applies a separate protocol comprising:
                      neuropsychological tests of attention, memory, executive
                      functions and language; examination of motor skills; ratings
                      of personality, life quality, mood and daily activities;
                      analysis of laboratory and genetic data; and
                      state-of-the-art magnetic resonance imaging (MRI, 3 Tesla)
                      of the brain. The latter includes (i) 3D-T1- and
                      3D-T2-weighted scans for structural analyses and myelin
                      mapping; (ii) three diffusion imaging sequences optimized
                      for diffusion tensor imaging, high-angular resolution
                      diffusion imaging for detailed fiber tracking and for
                      diffusion kurtosis imaging; (iii) resting-state and
                      task-based functional MRI; and (iv) fluid-attenuated
                      inversion recovery and MR angiography for the detection of
                      vascular lesions and the mapping of white matter lesions.
                      The unique design of 1000BRAINS allows: (i) comprehensive
                      investigation of various influences including genetics,
                      environment and health status on variability in brain
                      structure and function during aging; and (ii) identification
                      of the impact of selected influencing factors on specific
                      cognitive subsystems and their anatomical correlates.},
      cin          = {INM-1 / INM-4 / INM-8 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-8-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89571 - Connectivity and
                      Activity (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000340895500001},
      pubmed       = {pmid:25071558},
      doi          = {10.3389/fnagi.2014.00149},
      url          = {https://juser.fz-juelich.de/record/154147},
}