TY  - JOUR
AU  - Kohl, S.
AU  - Wolters, Carolin
AU  - Gruendler, Theo O. J.
AU  - Vogeley, Kai
AU  - Klosterkötter, Joachim
AU  - Kuhn, Jens
TI  - Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism
JO  - PLoS one
VL  - 9
IS  - 3
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - FZJ-2014-03593
SP  - e92372 -
PY  - 2014
AB  - High functioning autism is an autism spectrum disorder that is characterized by deficits in social interaction and communication as well as repetitive and restrictive behavior while intelligence and general cognitive functioning are preserved. According to the weak central coherence account, individuals with autism tend to process information detail-focused at the expense of global form. This processing bias might be reflected by deficits in sensorimotor gating, a mechanism that prevents overstimulation during the transformation of sensory input into motor action. Prepulse inhibition is an operational measure of sensorimotor gating, which indicates an extensive attenuation of the startle reflex that occurs when a startling pulse is preceded by a weaker stimulus, the prepulse.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000333259900128
C6  - pmid:24643088
DO  - DOI:10.1371/journal.pone.0092372
UR  - https://juser.fz-juelich.de/record/154214
ER  -