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@ARTICLE{Niessen:154324,
      author       = {Niessen, E. and Fink, G. R. and Weiss-Blankenhorn, Peter},
      title        = {{A}praxia, pantomime and the parietal cortex},
      journal      = {NeuroImage: Clinical},
      volume       = {5},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2014-03672},
      pages        = {42 - 52},
      year         = {2014},
      abstract     = {Apraxia, a disorder of higher motor cognition, is a
                      frequent and outcome-relevant sequel of left hemispheric
                      stroke. Deficient pantomiming of object use constitutes a
                      key symptom of apraxia and is assessed when testing for
                      apraxia. To date the neural basis of pantomime remains
                      controversial. We here review the literature and perform a
                      meta-analysis of the relevant structural and functional
                      imaging (fMRI/PET) studies.Based on a systematic literature
                      search, 10 structural and 12 functional imaging studies were
                      selected.Structural lesion studies associated pantomiming
                      deficits with left frontal, parietal and temporal lesions.
                      In contrast, functional imaging studies associate pantomimes
                      with left parietal activations, with or without concurrent
                      frontal or temporal activations. Functional imaging studies
                      that selectively activated parietal cortex adopted the most
                      stringent controls.In contrast to previous suggestions,
                      current analyses show that both lesion and functional
                      studies support the notion of a left-hemispheric
                      fronto-(temporal)-parietal network underlying pantomiming
                      object use. Furthermore, our review demonstrates that the
                      left parietal cortex plays a key role in pantomime-related
                      processes. More specifically, stringently controlled
                      fMRI-studies suggest that in addition to storing motor
                      schemas, left parietal cortex is also involved in activating
                      these motor schemas in the context of pantomiming object
                      use. In addition to inherent differences between structural
                      and functional imaging studies and consistent with the
                      dedifferentiation hypothesis, the age difference between
                      young healthy subjects (typically included in functional
                      imaging studies) and elderly neurological patients
                      (typically included in structural lesion studies) may well
                      contribute to the finding of a more distributed
                      representation of pantomiming within the motor-dominant left
                      hemisphere in the elderly},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000349667800006},
      pubmed       = {pmid:24967158},
      doi          = {10.1016/j.nicl.2014.05.017},
      url          = {https://juser.fz-juelich.de/record/154324},
}