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000154325 1001_ $$0P:(DE-Juel1)136686$$aRichter, Nils$$b0$$eCorresponding Author$$ufzj
000154325 245__ $$aThe integrity of the cholinergic system determines memory performance in healthy elderly
000154325 260__ $$aOrlando, Fla.$$bAcademic Press$$c2014
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000154325 520__ $$aThe cholinergic system plays a central role in episodic memory-related processes in health and disease. Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [11C]N-methyl-4-piperidyl acetate (MP4A). A close relationship between the kinetic constant k3 of MP4A and mnestic functions has been demonstrated for patients suffering from amnestic mild cognitive impairment and Alzheimer's disease. Under the hypothesis that AChE activity and memory are intimately linked in older age, we obtained MP4A-PET and structural magnetic resonance images as well as neuropsychological data from fourteen healthy older adults. Multiple regression analysis revealed that AChE activity in areas previously implicated in mnestic functions predicted episodic memory performance irrespective of cortical atrophy. Data suggest that in older adults the integrity of the cholinergic system underlies inter-individual variability in memory function.
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000154325 7001_ $$0P:(DE-HGF)0$$aAllendorf, Inka$$b1
000154325 7001_ $$0P:(DE-Juel1)131736$$aOnur, Özgür$$b2$$ufzj
000154325 7001_ $$0P:(DE-HGF)0$$aKracht, Lutz$$b3
000154325 7001_ $$0P:(DE-HGF)0$$aDietlein, Markus$$b4
000154325 7001_ $$0P:(DE-HGF)0$$aTittgemeyer, Marc$$b5
000154325 7001_ $$0P:(DE-HGF)0$$aNeumaier, Bernd$$b6
000154325 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b7$$ufzj
000154325 7001_ $$0P:(DE-Juel1)131730$$aKukolja, Juraj$$b8$$ufzj
000154325 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2014.06.031$$gp. S1053811914005084$$p481–488$$tNeuroImage$$v100$$x1053-8119$$y2014
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