TY  - JOUR
AU  - Richter, Nils
AU  - Allendorf, Inka
AU  - Onur, Özgür
AU  - Kracht, Lutz
AU  - Dietlein, Markus
AU  - Tittgemeyer, Marc
AU  - Neumaier, Bernd
AU  - Fink, Gereon R.
AU  - Kukolja, Juraj
TI  - The integrity of the cholinergic system determines memory performance in healthy elderly
JO  - NeuroImage
VL  - 100
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2014-03673
SP  - 481–488
PY  - 2014
AB  - The cholinergic system plays a central role in episodic memory-related processes in health and disease. Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [11C]N-methyl-4-piperidyl acetate (MP4A). A close relationship between the kinetic constant k3 of MP4A and mnestic functions has been demonstrated for patients suffering from amnestic mild cognitive impairment and Alzheimer's disease. Under the hypothesis that AChE activity and memory are intimately linked in older age, we obtained MP4A-PET and structural magnetic resonance images as well as neuropsychological data from fourteen healthy older adults. Multiple regression analysis revealed that AChE activity in areas previously implicated in mnestic functions predicted episodic memory performance irrespective of cortical atrophy. Data suggest that in older adults the integrity of the cholinergic system underlies inter-individual variability in memory function.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000344235800043
C6  - pmid:24952230
DO  - DOI:10.1016/j.neuroimage.2014.06.031
UR  - https://juser.fz-juelich.de/record/154325
ER  -