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@ARTICLE{Richter:154325,
      author       = {Richter, Nils and Allendorf, Inka and Onur, Özgür and
                      Kracht, Lutz and Dietlein, Markus and Tittgemeyer, Marc and
                      Neumaier, Bernd and Fink, Gereon R. and Kukolja, Juraj},
      title        = {{T}he integrity of the cholinergic system determines memory
                      performance in healthy elderly},
      journal      = {NeuroImage},
      volume       = {100},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2014-03673},
      pages        = {481–488},
      year         = {2014},
      abstract     = {The cholinergic system plays a central role in episodic
                      memory-related processes in health and disease. Cerebral
                      acetylcholinesterase (AChE) activity, a measure of the
                      integrity of the cholinergic system, can be assessed in vivo
                      using positron emission tomography (PET) and
                      [11C]N-methyl-4-piperidyl acetate (MP4A). A close
                      relationship between the kinetic constant k3 of MP4A and
                      mnestic functions has been demonstrated for patients
                      suffering from amnestic mild cognitive impairment and
                      Alzheimer's disease. Under the hypothesis that AChE activity
                      and memory are intimately linked in older age, we obtained
                      MP4A-PET and structural magnetic resonance images as well as
                      neuropsychological data from fourteen healthy older adults.
                      Multiple regression analysis revealed that AChE activity in
                      areas previously implicated in mnestic functions predicted
                      episodic memory performance irrespective of cortical
                      atrophy. Data suggest that in older adults the integrity of
                      the cholinergic system underlies inter-individual
                      variability in memory function.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000344235800043},
      pubmed       = {pmid:24952230},
      doi          = {10.1016/j.neuroimage.2014.06.031},
      url          = {https://juser.fz-juelich.de/record/154325},
}