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@ARTICLE{Schiller:154400,
      author       = {Schiller, Viktoria and Wichmann, Arne and Kriehuber, Ralf
                      and Schäfers, Christoph and Fischer, Rainer and Fenske,
                      Martina},
      title        = {{T}ranscriptome alterations in zebrafish embryos after
                      exposure to environmental estrogens and anti-androgens can
                      reveal endocrine disruption},
      journal      = {Reproductive toxicology},
      volume       = {42},
      issn         = {0890-6238},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2014-03747},
      pages        = {210 - 223},
      year         = {2013},
      abstract     = {Exposure to environmental chemicals known as endocrine
                      disruptors (EDs) is in many cases associated with an
                      unpredictable hazard for wildlife and human health. The
                      identification of endocrine disruptive properties of
                      chemicals certain to enter the aquatic environment relies on
                      toxicity tests with fish, assessing adverse effects on
                      reproduction and sexual development. The demand for quick,
                      reliable ED assays favored the use of fish embryos as
                      alternative test organisms. We investigated the application
                      of a transcriptomics-based assay for estrogenic and
                      anti-androgenic chemicals with zebrafish embryos. Two
                      reference compounds, 17α-ethinylestradiol and flutamide,
                      were tested to evaluate the effects on development and the
                      transcriptome after 48 h-exposures. Comparison of the
                      transcriptome response with other estrogenic and
                      anti-androgenic compounds (genistein, bisphenol A,
                      methylparaben, linuron, prochloraz, propanil) showed
                      commonalities and differences in regulated pathways,
                      enabling us to classify the estrogenic and anti-androgenic
                      potencies. This demonstrates that different mechanism of ED
                      can be assessed already in fish embryos.},
      cin          = {S-US},
      ddc          = {610},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000327569100023},
      pubmed       = {24051129},
      doi          = {10.1016/j.reprotox.2013.09.003},
      url          = {https://juser.fz-juelich.de/record/154400},
}