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@ARTICLE{Hohoff:154517,
      author       = {Hohoff, Christa and Garibotto, Valentina and Elmenhorst,
                      David and Baffa, Anna and Kroll, Tina and Hoffmann, Alana
                      and Schwarte, Kathrin and Zhang, Weiqi and Arolt, Volker and
                      Deckert, Jürgen and Bauer, Andreas},
      title        = {{A}ssociation of {A}denosine {R}eceptor {G}ene
                      {P}olymorphisms and {I}n {V}ivo {A}denosine {A}1 {R}eceptor
                      {B}inding in {T}he {H}uman {B}rain},
      journal      = {Neuropsychopharmacology},
      volume       = {39},
      issn         = {1740-634X},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {FZJ-2014-03831},
      pages        = {2989–2999},
      year         = {2014},
      abstract     = {Adenosine A1 receptors (A1ARs) and the interacting
                      adenosine A2A receptors are implicated in neurological and
                      psychiatric disorders. Variants within the corresponding
                      genes ADORA1 and ADORA2A were shown associated with
                      pathophysiologic alterations, particularly increased
                      anxiety. It is unknown so far, if these variants might
                      modulate the A1AR distribution and availability in different
                      brain regions. In this pilot study, the influence of ADORA1
                      and ADORA2A variants on in vivo A1AR binding was assessed
                      with the A1AR-selective positron emission tomography (PET)
                      radioligand [18F]CPFPX in brains of healthy humans.
                      Twenty-eight normal control subjects underwent PET
                      procedures to calculate the binding potential BPND of
                      [18F]CPFPX in cerebral regions and to assess ADORA1 and
                      ADORA2A single nucleotide polymorphism (SNP) effects on
                      regional BPND data. Our results revealed SNPs of both genes
                      associated with [18F]CPFPX binding to the A1AR. The
                      strongest effects that withstood even Bonferroni correction
                      of multiple SNP testing were found in non-smoking subjects
                      (N=22) for ADORA2A SNPs rs2236624 and rs5751876 (corr.
                      Pall<0.05). SNP alleles previously identified at risk for
                      increased anxiety like the rs5751876 T-allele corresponded
                      to consistently higher A1AR availability in all brain
                      regions. Our data indicate for the first time that variation
                      of A1AR availability was associated with ADORA SNPs. The
                      finding of increased A1AR availability in regions of the
                      fear network, particularly in ADORA2A risk allele carriers,
                      strongly warrants evaluation and replication in further
                      studies including individuals with increased
                      anxiety.Neuropsychopharmacology advance online publication},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89571 - Connectivity and
                      Activity (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000344834600007},
      pubmed       = {pmid:24943643},
      doi          = {10.1038/npp.2014.150},
      url          = {https://juser.fz-juelich.de/record/154517},
}