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@ARTICLE{Ripke:154823,
      author       = {Ripke, Stephan and Neale, Benjamin M. and Corvin, Aiden and
                      Walters, James T. R. and Farh, Kai-How and Holmans, Peter A.
                      and Lee, Phil and Bulik-Sullivan, Brendan and Collier, David
                      A. and Huang, Hailiang and Pers, Tune H. and Agartz, Ingrid
                      and Agerbo, Esben and Albus, Margot and Alexander, Madeline
                      and Amin, Farooq and Bacanu, Silviu A. and Begemann, Martin
                      and Belliveau Jr, Richard A. and Bene, Judit and Bergen,
                      Sarah E. and Bevilacqua, Elizabeth and Bigdeli, Tim B. and
                      Black, Donald W. and Bruggeman, Richard and Buccola, Nancy
                      G. and Buckner, Randy L. and Byerley, William and Cahn,
                      Wiepke and Cai, Guiqing and Campion, Dominique and Cantor,
                      Rita M. and Carr, Vaughan J. and Carrera, Noa and Catts,
                      Stanley V. and Chambert, Kimberly D. and Chan, Raymond C. K.
                      and Chen, Ronald Y. L. and Chen, Eric Y. H. and Cheng, Wei
                      and Cheung, Eric F. C. and Ann Chong, Siow and Robert
                      Cloninger, C. and Cohen, David and Cohen, Nadine and
                      Cormican, Paul and Craddock, Nick and Crowley, James J. and
                      Curtis, David and Davidson, Michael and Davis, Kenneth L.
                      and Degenhardt, Franziska and Del Favero, Jurgen and
                      Demontis, Ditte and Dikeos, Dimitris and Dinan, Timothy and
                      Djurovic, Srdjan and Donohoe, Gary and Drapeau, Elodie and
                      Duan, Jubao and Dudbridge, Frank and Durmishi, Naser and
                      Eichhammer, Peter and Eriksson, Johan and Escott-Price,
                      Valentina and Essioux, Laurent and Fanous, Ayman H. and
                      Farrell, Martilias S. and Frank, Josef and Franke, Lude and
                      Freedman, Robert and Freimer, Nelson B. and Friedl, Marion
                      and Friedman, Joseph I. and Fromer, Menachem and Genovese,
                      Giulio and Georgieva, Lyudmila and Giegling, Ina and
                      Giusti-Rodríguez, Paola and Godard, Stephanie and
                      Goldstein, Jacqueline I. and Golimbet, Vera and Gopal,
                      Srihari and Gratten, Jacob and de Haan, Lieuwe and Hammer,
                      Christian and Hamshere, Marian L. and Hansen, Mark and
                      Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette
                      M. and Henskens, Frans A. and Herms, Stefan and Hirschhorn,
                      Joel N. and Hoffmann, Per and Hofman, Andrea and Hollegaard,
                      Mads V. and Hougaard, David M. and Ikeda, Masashi and Joa,
                      Inge and Julià, Antonio and Kahn, René S. and Kalaydjieva,
                      Luba and Karachanak-Yankova, Sena and Karjalainen, Juha and
                      Kavanagh, David and Keller, Matthew C. and Kennedy, James L.
                      and Khrunin, Andrey and Kim, Yunjung and Klovins, Janis and
                      Knowles, James A. and Konte, Bettina and Kucinskas, Vaidutis
                      and Ausrele Kucinskiene, Zita and Kuzelova-Ptackova, Hana
                      and Kähler, Anna K. and Laurent, Claudine and Lee Chee
                      Keong, Jimmy and Hong Lee, S. and Legge, Sophie E. and
                      Lerer, Bernard and Li, Miaoxin and Li, Tao and Liang,
                      Kung-Yee and Lieberman, Jeffrey and Limborska, Svetlana and
                      Loughland, Carmel M. and Lubinski, Jan and Lönnqvist, Jouko
                      and Macek Jr, Milan and Magnusson, Patrik K. E. and Maher,
                      Brion S. and Maier, Wolfgang and Mallet, Jacques and Marsal,
                      Sara and Mattheisen, Manuel and Mattingsdal, Morten and
                      McCarley, Robert W. and McDonald, Colm and McIntosh, Andrew
                      M. and Meier, Sandra and Meijer, Carin J. and Melegh, Bela
                      and Melle, Ingrid and Mesholam-Gately, Raquelle I. and
                      Metspalu, Andres and Michie, Patricia T. and Milani, Lili
                      and Milanova, Vihra and Mokrab, Younes and Morris, Derek W.
                      and Mors, Ole and Murphy, Kieran C. and Murray, Robin M. and
                      Myin-Germeys, Inez and Müller-Myhsok, Bertram and Nelis,
                      Mari and Nenadic, Igor and Nertney, Deborah A. and Nestadt,
                      Gerald and Nicodemus, Kristin K. and Nikitina-Zake, Liene
                      and Nisenbaum, Laura and Nordin, Annelie and O’Callaghan,
                      Eadbhard and O’Dushlaine, Colm and O’Neill, F. Anthony
                      and Oh, Sang-Yun and Olincy, Ann and Olsen, Line and Van Os,
                      Jim and Endophenotypes International Consortium, Psychosis
                      and Pantelis, Christos and Papadimitriou, George N. and
                      Papiol, Sergi and Parkhomenko, Elena and Pato, Michele T.
                      and Paunio, Tiina and Pejovic-Milovancevic, Milica and
                      Perkins, Diana O. and Pietiläinen, Olli and Pimm, Jonathan
                      and Pocklington, Andrew J. and Powell, John and Price, Alkes
                      and Pulver, Ann E. and Purcell, Shaun M. and Quested, Digby
                      and Rasmussen, Henrik B. and Reichenberg, Abraham and
                      Reimers, Mark A. and Richards, Alexander L. and Roffman,
                      Joshua L. and Roussos, Panos and Ruderfer, Douglas M. and
                      Salomaa, Veikko and Sanders, Alan R. and Schall, Ulrich and
                      Schubert, Christian R. and Schulze, Thomas G. and Schwab,
                      Sibylle G. and Scolnick, Edward M. and Scott, Rodney J. and
                      Seidman, Larry J. and Shi, Jianxin and Sigurdsson, Engilbert
                      and Silagadze, Teimuraz and Silverman, Jeremy M. and Sim,
                      Kang and Slominsky, Petr and Smoller, Jordan W. and So,
                      Hon-Cheong and Spencer, ChrisC. A. and Stahl, Eli A. and
                      Stefansson, Hreinn and Steinberg, Stacy and Stogmann,
                      Elisabeth and Straub, Richard E. and Strengman, Eric and
                      Strohmaier, Jana and Scott Stroup, T. and Subramaniam,
                      Mythily and Suvisaari, Jaana and Svrakic, Dragan M. and
                      Szatkiewicz, Jin P. and Söderman, Erik and Thirumalai,
                      Srinivas and Toncheva, Draga and Tosato, Sarah and Veijola,
                      Juha and Waddington, John and Walsh, Dermot and Wang, Dai
                      and Wang, Qiang and Webb, Bradley T. and Weiser, Mark and
                      Wildenauer, Dieter B. and Williams, Nigel M. and Williams,
                      Stephanie and Witt, Stephanie H. and Wolen, Aaron R. and
                      Wong, Emily H. M. and Wormley, Brandon K. and Simon Xi,
                      Hualin and Zai, Clement C. and Zheng, Xuebin and Zimprich,
                      Fritz and Wray, Naomi R. and Stefansson, Kari and Visscher,
                      Peter M. and Trust Case-Control Consortium, Wellcome and
                      Adolfsson, Rolf and Andreassen, Ole A. and Blackwood,
                      Douglas H. R. and Bramon, Elvira and Buxbaum, Joseph D. and
                      Børglum, Anders D. and Cichon, Sven and Darvasi, Ariel and
                      Domenici, Enrico and Ehrenreich, Hannelore and Esko, Tõnu
                      and Gejman, Pablo V. and Gill, Michael and Gurling, Hugh and
                      Hultman, Christina M. and Iwata, Nakao and Jablensky, Assen
                      V. and Jönsson, Erik G. and Kendler, Kenneth S. and Kirov,
                      George and Knight, Jo and Lencz, Todd and Levinson, Douglas
                      F. and Li, Qingqin S. and Liu, Jianjun and Malhotra, Anil K.
                      and McCarroll, Steven A. and McQuillin, Andrew and Moran,
                      Jennifer L. and Mortensen, Preben B. and Mowry, Bryan J. and
                      Nöthen, Markus M. and Ophoff, Roel A. and Owen, Michael J.
                      and Palotie, Aarno and Pato, Carlos N. and Petryshen, Tracey
                      L. and Posthuma, Danielle and Rietschel, Marcella and Riley,
                      Brien P. and Rujescu, Dan and Sham, Pak C. and Sklar, Pamela
                      and St Clair, David and Weinberger, Daniel R. and Wendland,
                      Jens R. and Werge, Thomas and Daly, Mark J. and Sullivan,
                      Patrick F. and O’Donovan, Michael C.},
      title        = {{B}iological insights from 108 schizophrenia-associated
                      genetic loci},
      journal      = {Nature},
      volume       = {511},
      number       = {7510},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publising Group},
      reportid     = {FZJ-2014-04091},
      pages        = {421 - 427},
      year         = {2014},
      abstract     = {Schizophrenia is a highly heritable disorder. Genetic risk
                      is conferred by a large number of alleles, including common
                      alleles of small effect that might be detected by
                      genome-wide association studies. Here we report a
                      multi-stage schizophrenia genome-wide association study of
                      up to 36,989 cases and 113,075 controls. We identify 128
                      independent associations spanning 108 conservatively defined
                      loci that meet genome-wide significance, 83 of which have
                      not been previously reported. Associations were enriched
                      among genes expressed in brain, providing biological
                      plausibility for the findings. Many findings have the
                      potential to provide entirely new insights into aetiology,
                      but associations at DRD2 and several genes involved in
                      glutamatergic neurotransmission highlight molecules of known
                      and potential therapeutic relevance to schizophrenia, and
                      are consistent with leading pathophysiological hypotheses.
                      Independent of genes expressed in brain, associations were
                      enriched among genes expressed in tissues that have
                      important roles in immunity, providing support for the
                      speculated link between the immune system and
                      schizophrenia.},
      cin          = {INM-1},
      ddc          = {070},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89571 - Connectivity and
                      Activity (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000339335700037},
      pubmed       = {pmid:25056061},
      doi          = {10.1038/nature13595},
      url          = {https://juser.fz-juelich.de/record/154823},
}