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@ARTICLE{Klein:154901,
      author       = {Klein, G. and Burghaus, L. and Vaillant, M. and Pieri, V.
                      and Fink, G. R. and Diederich, N.},
      title        = {{D}ysautonomia in narcolepsy: {E}vidence by questionnaire
                      assessment},
      journal      = {Journal of clinical neurology},
      volume       = {10},
      number       = {4},
      issn         = {2005-5013},
      address      = {Seoul},
      publisher    = {PubMed Central, Korean Neurological Association},
      reportid     = {FZJ-2014-04131},
      pages        = {314-319},
      year         = {2014},
      abstract     = {Background and PurposeExcessive daytime sleepiness and
                      sudden sleep attacks are the main features of narcolepsy,
                      but rapid-eye-movement sleep behavior disorder (RBD),
                      hyposmia, and depression can also occur. The latter symptoms
                      are nonmotor features in idiopathic Parkinson's disease
                      (IPD). In the present study, IPD-proven diagnostic tools
                      were tested to determine whether they are also applicable in
                      the assessment of narcolepsy.MethodsThis was a case-control
                      study comparing 15 patients with narcolepsy (PN) and 15
                      control subjects (CS) using the Scales for Outcomes in
                      Parkinson's Autonomic Test (SCOPA-AUT), Parkinson's Disease
                      Nonmotor Symptoms (PDNMS), University of Pennsylvania Smell
                      Test, Farnsworth-Munsell 100 Hue test, Beck Depression
                      Inventory, and the RBD screening questionnaire.ResultsBoth
                      the PN and CS exhibited mild hyposmia and no deficits in
                      visual tests. Frequent dysautonomia in all domains except
                      sexuality was found for the PN. The total SCOPA-AUT score
                      was higher for the PN (18.47±10.08, mean±SD) than for the
                      CS (4.40±3.09), as was the PDNMS score (10.53±4.78 and
                      1.80±2.31, respectively). RBD was present in $87\%$ of the
                      PN and $0\%$ of the CS. The PN were more depressed than the
                      CS. The differences between the PN and CS for all of these
                      variables were statistically significant (all
                      p<0.05).ConclusionsThe results of this study provide
                      evidence for the presence of dysautonomia and confirm the
                      comorbidities of depression and RBD in narcolepsy patients.
                      The spectrum, which is comparable to the nonmotor complex in
                      IPD, suggests wide-ranging, clinically detectable
                      dysfunction beyond the narcoleptic core syndrome.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000342657300005},
      pubmed       = {pmid:25324880},
      doi          = {10.3988/jcn.2014.10.4.314},
      url          = {https://juser.fz-juelich.de/record/154901},
}