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000154928 1001_ $$0P:(DE-Juel1)131814$$aCardinale, Jens$$b0$$eCorresponding Author$$ufzj
000154928 245__ $$aIodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F]fluorophenoxy)-phenylmethyl)piperidine NET and SERT ligands
000154928 260__ $$aLondon$$bRSC Publishing$$c2014
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000154928 520__ $$aIodonium ylide precursors of electron rich arenes, i.e. the NET and SERT ligands 4-((3- and 4-fluorophenoxy)phenylmethyl)piperidine, served as model compounds for the direct substitution with n.c.a. [18F]fluoride. Good radiochemical yields of about 20% were obtained in reaction times of ca. 130 minutes with a molar activity of the labelled ligands of more than 50 GBq μmol−1. Those failed as in vivo probes in first evaluation studies. Several important insights, however, were gained into the reaction of ylides, e.g. an unexpected formation of regioisomers. The results clearly demonstrate that aryliodonium ylides are a promising alternative to the well-known diaryliodonium salts for the direct preparation of complex, electron rich n.c.a. [18F]fluoroarenes.
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000154928 7001_ $$0P:(DE-Juel1)131818$$aErmert, Johannes$$b1$$ufzj
000154928 7001_ $$0P:(DE-HGF)0$$aHumpert, Sven$$b2
000154928 7001_ $$0P:(DE-Juel1)131816$$aCoenen, Heinrich Hubert$$b3$$ufzj
000154928 773__ $$0PERI:(DE-600)2623224-8$$a10.1039/c4ra00674g$$gVol. 4, no. 33, p. 17293 -$$n33$$p17293 -17299$$tRSC Advances$$v4$$x2046-2069$$y2014
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000154928 9132_ $$0G:(DE-HGF)POF3-573$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vNeuroimaging$$x0
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