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@ARTICLE{Cardinale:154928,
      author       = {Cardinale, Jens and Ermert, Johannes and Humpert, Sven and
                      Coenen, Heinrich Hubert},
      title        = {{I}odonium ylides for one-step, no-carrier-added
                      radiofluorination of electron rich arenes, exemplified with
                      4-(([18{F}]fluorophenoxy)-phenylmethyl)piperidine {NET} and
                      {SERT} ligands},
      journal      = {RSC Advances},
      volume       = {4},
      number       = {33},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2014-04139},
      pages        = {17293 -17299},
      year         = {2014},
      abstract     = {Iodonium ylide precursors of electron rich arenes, i.e. the
                      NET and SERT ligands 4-((3- and
                      4-fluorophenoxy)phenylmethyl)piperidine, served as model
                      compounds for the direct substitution with n.c.a.
                      [18F]fluoride. Good radiochemical yields of about $20\%$
                      were obtained in reaction times of ca. 130 minutes with a
                      molar activity of the labelled ligands of more than 50 GBq
                      μmol−1. Those failed as in vivo probes in first
                      evaluation studies. Several important insights, however,
                      were gained into the reaction of ylides, e.g. an unexpected
                      formation of regioisomers. The results clearly demonstrate
                      that aryliodonium ylides are a promising alternative to the
                      well-known diaryliodonium salts for the direct preparation
                      of complex, electron rich n.c.a. [18F]fluoroarenes.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89573 - Neuroimaging
                      (POF2-89573)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000335226700058},
      doi          = {10.1039/c4ra00674g},
      url          = {https://juser.fz-juelich.de/record/154928},
}