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@ARTICLE{Kickingereder:155421,
      author       = {Kickingereder, P. and Hamisch, C. and Suchorska, B. and
                      Galldiks, N. and Goldbrunner, R. and Kocher, M. and Treuer,
                      H. and Voges, J. and Ruge, M. I.},
      title        = {{L}ow-dose rate stereotactic iodine-125 brachytherapy for
                      the treatment of inoperable primary and recurrent
                      glioblastoma: single-center experience with 201 cases},
      journal      = {Journal of neuro-oncology},
      volume       = {120},
      number       = {3},
      issn         = {0167-594x},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {FZJ-2014-04587},
      pages        = {615-623},
      year         = {2014},
      abstract     = {Treatment options for inoperable glioblastoma are limited.
                      Low-dose-rate stereotactic iodine-125 brachytherapy (SBT)
                      has been reported as an effective and low-risk treatment
                      option for circumscribed low-grade gliomas and brain
                      metastases. The present study evaluates this treatment
                      approach for patients with inoperable glioblastoma. Between
                      1990 and 2012, 201 patients with histologically proven
                      glioblastoma were treated with SBT (iodine-125 seeds; median
                      cumulative surface dose, 60 Gy; median dose-rate, 6 cGy/h;
                      median gross-tumor-volume, 17 ml) either as primary
                      treatment (n = 103) or at recurrence (n = 98). In addition
                      to SBT, 90.3 $\%$ of patients in the primary treatment group
                      received external boost radiotherapy (median dose, 25.2 Gy).
                      Adjuvant chemotherapy was added for 30.8 $\%$ of patients
                      following SBT and consisted of temozolomide for the majority
                      of cases (88.7 $\%).$ Procedure-related complications,
                      clinical outcome, progression-free and overall survival
                      (PFS, OS) were evaluated. Median follow-up was 9.8 months.
                      The procedure-related mortality was zero. During follow-up,
                      transient and permanent procedure-related morbidity was
                      observed in 7.5 and 2.0 $\%,$ respectively. Calculated from
                      the time of SBT, median OS and PFS rates were 10.5 and 6.2
                      months, with no significant differences among primary and
                      recurrent tumors (11.1 vs.10.4 months for OS and 6.2 vs. 5.9
                      months for PFS). For OS, multivariate analysis revealed
                      Karnofsky performance score, age, and adjuvant chemotherapy
                      as independent prognostic factors (all p < 0.01).
                      Low-dose-rate SBT is a relatively safe and potentially
                      effective local treatment option for patients with
                      circumscribed inoperable glioblastoma initially or at
                      recurrence. It deserves prospective validation since it may
                      improve the outcome for a subset of patients with inoperable
                      GBM.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000345286700022},
      doi          = {10.1007/s11060-014-1595-y},
      url          = {https://juser.fz-juelich.de/record/155421},
}