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@ARTICLE{Schmiele:155631,
author = {Schmiele, Martin and Schindler, Torben and Westermann,
Martin and Steiniger, Frank and Radulescu, Aurel and Kriele,
Armin and Gilles, Ralph and Unruh, Tobias},
title = {{M}esoscopic {S}tructures of {T}riglyceride
{N}anosuspensions {S}tudied by {S}mall-{A}ngle {X}-ray and
{N}eutron {S}cattering and {C}omputer {S}imulations},
journal = {The journal of physical chemistry / B},
volume = {118},
number = {29},
issn = {1520-5207},
address = {Washington, DC},
publisher = {Soc.},
reportid = {FZJ-2014-04689},
pages = {8808 - 8818},
year = {2014},
abstract = {Aqueous suspensions of platelet-like shaped tripalmitin
nanocrystals are studied here at high tripalmitin
concentrations (10 wt $\%$ tripalmitin) for the first time
by a combination of small-angle X-ray and neutron scattering
(SAXS and SANS). The suspensions are stabilized by different
lecithins, namely, DLPC, DOPC, and the lecithin blend S100.
At such high concentrations the platelets start to
self-assemble in stacks, which causes interference maxima at
low Q-values in the SAXS and SANS patterns, respectively. It
is found that the stack-related interference maxima are more
pronounced for the suspension stabilized with DOPC and in
particular DLPC, compared to suspensions stabilized by S100.
By use of the X-ray and neutron powder pattern simulation
analysis (XNPPSA), the SAXS and SANS patterns of the native
tripalmitin suspensions could only be reproduced
simultaneously when assuming the presence of both isolated
nanocrystals and stacks of nanocrystals of different size in
the simulation model of the dispersions. By a fit of the
simulated SAXS and SANS patterns to the experimental data, a
distribution of the stack sizes and their volume fractions
is determined. The volume fraction of stacklike platelet
assemblies is found to rise from $70\%$ for S100-stabilized
suspensions to almost $100\%$ for the DLPC-stabilized
suspensions. The distribution of the platelet thicknesses
could be determined with molecular resolution from a
combined analysis of the SAXS and SANS patterns of the
corresponding diluted tripalmitin (3 wt $\%)$ suspensions.
In accordance with microcalorimetric data, it could be
concluded that the platelets in the suspensions stabilized
with DOPC, and in particular DLPC, are significantly thinner
than those stabilized with S100. The DLPC-stabilized
suspensions exhibit a significantly narrower platelet
thickness distribution compared to DOPC- and S100-stabilized
suspensions. The smaller thicknesses for the DLPC- and
DOPC-stabilized platelets explain their higher tendency to
self-assemble in stacks. The finding that the nanoparticles
of the suspension stabilized by the saturated lecithin DLPC
crystallize in the stable β-tripalmitin modification with
its characteristic platelet-like shape is surprising and can
be explained by the fact that the main phase transformation
temperature for DLPC is, as for unsaturated lecithins like
DOPC and S100, well below the crystallization temperature of
the supercooled tripalmitin emulsion droplets.},
cin = {Neutronenstreuung ; JCNS-1 / JCNS (München) ; Jülich
Centre for Neutron Science JCNS (München) ; JCNS-FRM-II /
ICS-1},
ddc = {530},
cid = {I:(DE-Juel1)JCNS-1-20110106 /
I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)ICS-1-20110106},
pnm = {451 - Soft Matter Composites (POF2-451) / 54G - JCNS
(POF2-54G24)},
pid = {G:(DE-HGF)POF2-451 / G:(DE-HGF)POF2-54G24},
experiment = {EXP:(DE-MLZ)KWS2-20140101},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000339540600038},
doi = {10.1021/jp502580a},
url = {https://juser.fz-juelich.de/record/155631},
}