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@ARTICLE{Dasgupta:155676,
      author       = {Dasgupta, Sabyasachi and Auth, Thorsten and Gov, Nir S.
                      and Satchwell, Timothy J. and Hanssen, Eric and Zuccala,
                      Elizabeth S. and Riglar, David T. and Toye, Ashley M. and
                      Betz, Timo and Baum, Jake and Gompper, Gerhard},
      title        = {{M}embrane-{W}rapping {C}ontributions to {M}alaria
                      {P}arasite {I}nvasion of the {H}uman {E}rythrocyte},
      journal      = {Biophysical journal},
      volume       = {107},
      number       = {1},
      issn         = {0006-3495},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {FZJ-2014-04729},
      pages        = {43 - 54},
      year         = {2014},
      abstract     = {The blood stage malaria parasite, the merozoite, has a
                      small window of opportunity during which it must
                      successfully target and invade a human erythrocyte. The
                      process of invasion is nonetheless remarkably rapid. To
                      date, mechanistic models of invasion have focused
                      predominantly on the parasite actomyosin motor contribution
                      to the energetics of entry. Here, we have conducted a
                      numerical analysis using dimensions for an archetypal
                      merozoite to predict the respective contributions of the
                      host-parasite interactions to invasion, in particular the
                      role of membrane wrapping. Our theoretical modeling
                      demonstrates that erythrocyte membrane wrapping alone, as a
                      function of merozoite adhesive and shape properties, is
                      sufficient to entirely account for the first key step of the
                      invasion process, that of merozoite reorientation to its
                      apex and tight adhesive linkage between the two cells. Next,
                      parasite-induced reorganization of the erythrocyte
                      cytoskeleton and release of parasite-derived membrane can
                      also account for a considerable energetic portion of actual
                      invasion itself, through membrane wrapping. Thus, contrary
                      to the prevailing dogma, wrapping by the erythrocyte
                      combined with parasite-derived membrane release can markedly
                      reduce the expected contributions of the merozoite
                      actomyosin motor to invasion. We therefore propose that
                      invasion is a balance between parasite and host cell
                      contributions, evolved toward maximal efficient use of
                      biophysical forces between the two cells.},
      cin          = {IAS-2 / ICS-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {451 - Soft Matter Composites (POF2-451)},
      pid          = {G:(DE-HGF)POF2-451},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000338411600009},
      pubmed       = {pmid:24988340},
      doi          = {10.1016/j.bpj.2014.05.024},
      url          = {https://juser.fz-juelich.de/record/155676},
}